Lin Yao-Tsung, Lan Kuo-Mao, Wang Li-Kai, Chen Jen-Yin
From the Department of Anesthesiology, Chi Mei Medical Center, Tainan, Taiwan.
Department of Food Science and Applied Biotechnology, National Chung Hsing University, Taichung, Taiwan.
A A Pract. 2018 Jul 1;11(1):8-10. doi: 10.1213/XAA.0000000000000712.
Gabapentinoids (gabapentin and pregabalin) are first-line drugs for postherpetic neuralgia (PHN), but some PHN patients have inadequate therapeutic response. Zinc deficiency has been identified as a risk factor for PHN. Zinc can alleviate pain through binding to Ca(v)3.2 T-channels and N-methyl-D-aspartate receptors. Mechanisms of gabapentinoids on neuropathic pain include inhibiting N-methyl-D-aspartate receptors and calcium channels. The aforementioned findings provide a molecular pain-relieving basis for zinc supplements as an add-on therapy to pregabalin. We report 2 zinc-deficient PHN patients who received zinc sulfate intravenously as an add-on therapy to pregabalin and responded well.
加巴喷丁类药物（加巴喷丁和普瑞巴林）是治疗带状疱疹后神经痛（PHN）的一线药物，但一些PHN患者的治疗反应欠佳。锌缺乏已被确定为PHN的一个风险因素。锌可通过与Ca(v)3.2 T型通道和N-甲基-D-天冬氨酸受体结合来减轻疼痛。加巴喷丁类药物治疗神经性疼痛的机制包括抑制N-甲基-D-天冬氨酸受体和钙通道。上述研究结果为补充锌作为普瑞巴林附加治疗的分子止痛基础提供了依据。我们报告了2例锌缺乏的PHN患者，他们接受了静脉注射硫酸锌作为普瑞巴林的附加治疗，反应良好。
