Gálvez Rafael, Maire Coralie, Tovar Isabel, Vargas Pilar
From the Pain Unit Department of Anesthesia.
Radiotherapy Service, Hospital Virgen de las Nieves, Granada, Spain.
A A Pract. 2018 Jul 1;11(1):22-24. doi: 10.1213/XAA.0000000000000726.
Opioid-induced constipation (OIC) is a common gastrointestinal adverse effect of opioids, which can severely affect compliance and adherence to pain medication regimens and quality of life. Naloxegol has demonstrated efficacy against OIC in several studies involving patients with nonmalignant chronic pain. Here we report efficacy and tolerability of naloxegol in a 68-year-old patient with metastatic lung cancer and severe pain, treated with opioids, who presented with OIC resistant to traditional measures. Addition of naloxegol produced rapid improvement in his OIC symptoms and no apparent adverse effects while taking extended-release morphine 130 mg orally every 12 hours.
阿片类药物引起的便秘（OIC）是阿片类药物常见的胃肠道不良反应，可严重影响疼痛药物治疗方案的依从性和生活质量。在多项涉及非恶性慢性疼痛患者的研究中，纳洛西醇已证明对OIC有效。在此，我们报告了纳洛西醇在一名68岁转移性肺癌且伴有严重疼痛的患者中的疗效和耐受性，该患者接受阿片类药物治疗，出现对传统措施耐药的OIC。添加纳洛西醇后，他的OIC症状迅速改善，在每12小时口服130毫克缓释吗啡时未出现明显不良反应。
