泪腺腺癌保眼手术后辅助放疗：37例患者的治疗结果
Eye-Preserving Surgery Followed by Adjuvant Radiotherapy for Lacrimal Gland Carcinoma: Outcomes in 37 Patients.
作者信息
Woo Kyung In, Sagiv Oded, Han Jisang, Frank Steven J, Kim Yoon-Duck, Esmaeli Bita
机构信息
Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, U.S.A.
出版信息
Ophthalmic Plast Reconstr Surg. 2018 Nov/Dec;34(6):570-574. doi: 10.1097/IOP.0000000000001106.
PURPOSE
To describe the clinical outcomes of eye-preserving surgery followed by adjuvant radiotherapy in patients with lacrimal gland carcinoma.
METHODS
Thirty-seven patients with lacrimal gland carcinoma who underwent eye-preserving surgery were studied.
RESULTS
At last follow up, 32 patients were alive without disease, 3 patients were alive with disease with distant metastasis, 1 patient had died of disease, and 1 patient had died of other cause. The 5-year recurrence-free survival rate was worse in patients without than in patients with adjuvant radiotherapy (p = 0.001) and worse in patients with T3-T4 tumors than in patients with T1-T2 tumors (p = 0.027). At last follow up, 25 patients (68%) had visual acuity of 20/40 or better.
CONCLUSIONS
In patients with lacrimal gland carcinoma, eye-preserving surgery and adjuvant radiotherapy is associated with reasonable local control rates and visual and ocular function. Postoperative adjuvant radiotherapy seems to enhance local control rates.
目的
描述泪腺腺样囊性癌患者行保眼手术联合辅助放疗后的临床结局。
方法
对37例行保眼手术的泪腺腺样囊性癌患者进行研究。
结果
末次随访时，32例患者无病存活，3例患者带瘤存活且有远处转移，1例患者死于疾病，1例患者死于其他原因。未接受辅助放疗患者的5年无复发生存率低于接受辅助放疗的患者（p = 0.001），T3 - T4期肿瘤患者的5年无复发生存率低于T1 - T2期肿瘤患者（p = 0.027）。末次随访时，25例患者（68%）的视力为20/40或更好。
结论
对于泪腺腺样囊性癌患者，保眼手术联合辅助放疗可获得合理的局部控制率以及视觉和眼功能。术后辅助放疗似乎可提高局部控制率。
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