Kumari Rashmi, Saha Bhawesh Chandra, Sinha Bibhuti Prasanna, Mohan Nilesh
Nepal J Ophthalmol. 2017 Jul;9(18):128-135. doi: 10.3126/nepjoph.v9i2.19257.
The aim of the study was to evaluate and compare the efficacy, side effects and recurrence rate of vernal kerato conjunctivitis (VKC) with 0.03% tacrolimus and 0.05% cyclosporin.
A prospective randomised double blinded comparative study was conducted at a tertiary eye center. 46 Patients of VKC between March 2015- August 2015 were randomly divided into two groups and treated for 6weeks with either Tacrolimus(0.03%) eye ointment BD or Cyclosporine (0.05%) eyedrops QID.The main outcome measures were scoring and comparison of Total subjective symptom scores (TSSS) and Total objective ocular sign scores (TOSS) within and between the Groups at each follow up.Thirty two patients, sixteen from each group, with comparable baseline characters were analysed.
With treatment both TSSS and TOSS decreased consistently in both groups without any adverse effects but an increase in scores was noticed within two weeks after drug withdrawal.
Both drugs are equally effective and safe in VKC but with short lasting effect.
本研究旨在评估和比较0.03%他克莫司和0.05%环孢素治疗春季角结膜炎（VKC）的疗效、副作用及复发率。
在一家三级眼科中心进行了一项前瞻性随机双盲对照研究。2015年3月至2015年8月期间的46例VKC患者被随机分为两组，分别使用他克莫司（0.03%）眼膏每日两次或环孢素（0.05%）滴眼液每日四次治疗6周。主要观察指标为每次随访时组内及组间的总主观症状评分（TSSS）和总客观眼部体征评分（TOSS）的评分及比较。分析了32例患者，每组16例，其基线特征具有可比性。
治疗后两组的TSSS和TOSS均持续下降，且无任何不良反应，但停药后两周内评分有所上升。
两种药物在治疗VKC时同样有效且安全，但疗效持续时间较短。
