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长链多不饱和脂肪酸补充对哺乳期低出生体重儿智力的影响：荟萃分析。

The effect of long chain polyunsaturated fatty acid supplementation on intelligence in low birth weight infant during lactation: A meta-analysis.

机构信息

Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, China.

Department of Gastroenterology, Jilin Province People's Hospital, Changchun, China.

出版信息

PLoS One. 2018 Apr 10;13(4):e0195662. doi: 10.1371/journal.pone.0195662. eCollection 2018.

DOI:10.1371/journal.pone.0195662
PMID:29634752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5892917/
Abstract

BACKGROUND

Low birth weight infant (LBWIs) are prone to mental and behavioural problems. As an important constituent of the brain and retina, long chain polyunsaturated fatty acids are essential for foetal infant mental and visual development. The effect of lactation supplemented with long chain polyunsaturated fatty acids (LCPUFA) on the improvement of intelligence in low birth weight children requires further validation.

METHODS

In this study, a comprehensive search of multiple databases was performed to identify studies focused the association between intelligence and long chain polyunsaturated fatty acid supplementation in LBWIs. Studies that compared the Bayley Scales of Infant Development (BSID) or the Wechsler Abbreviated Scale of Intelligence for Children (WISC) scores between LBWIs who were supplemented and controls that were not supplemented with LCPUFA during lactation were selected for inclusion in the meta-analysis.

RESULTS

The main outcome was the mean difference in the mental development index (MDI) and psychomotor development index (PDI) of the BSID and the full scale intelligence quotient (FSIQ), verbal intelligence quotient (VIQ) and performance intelligence quotient (PIQ) of the WISC between LBWIs and controls. Our findings indicated that the mean BSID or WISC scores in LBWIs did not differ between the supplemented groups and controls.

CONCLUSION

This meta-analysis does not reveal that LCPUFA supplementation has a significant impact on the level of intelligence in LBWIs.

摘要

背景

低出生体重婴儿（LBWIs）易出现精神和行为问题。长链多不饱和脂肪酸作为大脑和视网膜的重要组成部分，对胎儿的精神和视觉发育至关重要。母乳喂养中添加长链多不饱和脂肪酸（LCPUFA）对改善低出生体重儿童智力的效果需要进一步验证。

方法

本研究通过综合检索多个数据库，对关注 LBWIs 中智力与长链多不饱和脂肪酸补充之间关系的研究进行了分析。选择了比较 LBWIs 中接受和未接受 LCPUFA 补充的母乳喂养婴儿在贝利婴幼儿发展量表（BSID）或韦氏儿童智力量表（WISC）评分之间差异的研究进行荟萃分析。

结果

主要结果是 LBWIs 与对照组之间的贝利婴幼儿发展量表（BSID）的精神发育指数（MDI）和运动发育指数（PDI）以及韦氏儿童智力量表（WISC）的全量表智商（FSIQ）、言语智商（VIQ）和操作智商（PIQ）的平均差异。我们的研究结果表明，LBWIs 中补充组和对照组的 BSID 或 WISC 平均评分没有差异。

结论

这项荟萃分析并未表明 LCPUFA 补充对 LBWIs 的智力水平有显著影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a2b/5892917/173ceade7d42/pone.0195662.g014.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a2b/5892917/173ceade7d42/pone.0195662.g014.jpg

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