School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur 492 010, Chhattisgarh, India.
Centre for Interdisciplinary Research in Basic Sciences, JMI, Jamia Nagar, New Delhi 110 025, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2018 Jun 15;199:376-386. doi: 10.1016/j.saa.2018.03.079. Epub 2018 Apr 2.
Aggregation behavior of bio-surfactants (BS) sodium cholate (NaC) and sodium deoxycholate (NaDC) within aqueous solution of ionic liquid (IL) 1-ethyl-3-methylimidazolium bromide [Emim][Br] has been investigated using surface tension, conductivity, steady state fluorescence, FT-IR and dynamic light scattering (DLS) techniques. Various interfacial and thermodynamic parameters are determined in the presence of different wt% of IL [Emim][Br]. Information regarding the local microenvironment and size of the aggregates is obtained from fluorescence and DLS, respectively. FT-IR spectral response is used to reveal the interactions taking place within aqueous NaC/NaDC micellar solutions. It is noteworthy to mention that increasing wt% of [Emim][Br] results in an increase in the spontaneity of micelle formation and the hydrophilic IL shows more affinity for NaC as compared to NaDC. Further, the micellar solutions of BS-[Emim][Br] are utilized for studying the aggregation of antidepressants drug promazine hydrochloride (pH). UV-vis spectroscopic investigation reveals interesting outcomes and the results show changes in spectral absorbance of PH drug on the addition of micellar solution (BS-[Emim][Br]). Highest binding affinity and most promising activity are shown for NaC as compared to NaDC.
采用表面张力、电导率、稳态荧光、FT-IR 和动态光散射（DLS）技术研究了生物表面活性剂（BS）胆酸钠（NaC）和脱氧胆酸钠（NaDC）在离子液体（IL）1-乙基-3-甲基咪唑溴化物[Emim][Br]水溶液中的聚集行为。在不同 wt%的 IL [Emim][Br]存在下，确定了各种界面和热力学参数。荧光和 DLS 分别获得有关聚集的局部微环境和大小的信息。FT-IR 光谱响应用于揭示水相 NaC/NaDC 胶束溶液中发生的相互作用。值得一提的是，[Emim][Br]wt%的增加导致胶束形成的自发性增加，亲水性 IL 与 NaDC 相比对 NaC 具有更高的亲和力。此外，BS-[Emim][Br]胶束溶液用于研究抗抑郁药盐酸普罗嗪（pH）的聚集。紫外可见光谱研究揭示了有趣的结果，结果表明在加入胶束溶液（BS-[Emim][Br]）时，PH 药物的光谱吸光度发生变化。与 NaDC 相比，NaC 表现出最高的结合亲和力和最有前途的活性。
