Lucarini A R, Salvetti A
Cattedra di Terapia Medica, University of Pisa, Italy.
Am J Cardiol. 1988 Feb 10;61(5):45C-48C. doi: 10.1016/0002-9149(88)90484-5.
To evaluate the humoral and hemodynamic (both systemic and renal) effects of celiprolol and to assess whether these effects are at least partially due to the activation of dopamine (DA) receptors, 9 out-patients with mild to moderate uncomplicated essential hypertension, without any therapy for at least 3 weeks, received celiprolol (400 mg once daily) and placebo, each for 1 month, according to a double-blind randomized trial pattern. At the end of each treatment period, blood pressure, heart rate, renal plasma flow, glomerular filtration rate, plasma renin activity, plasma aldosterone and plasma norepinephrine were measured after administration of saline solution and intravenous metoclopramide. Compared with placebo, celiprolol significantly reduced mean blood pressure, heart rate and plasma norepinephrine. Plasma renin activity showed a tendency toward a reduction during celiprolol treatment, which was not associated with changes in plasma aldosterone. Despite the decrease in mean blood pressure, renal plasma flow did not change, so that renovascular resistances were significantly reduced. Glomerular filtration rate was unchanged and the filtration fraction showed a trend toward a reduction during celiprolol treatment. Percent decrements of renovascular resistances and of mean blood pressure induced by celiprolol tended to correlate with changes in plasma norepinephrine. Metoclopramide did not influence the hemodynamic (systemic and renal) effects of celiprolol nor plasma renin activity and plasma norepinephrine, and it increased aldosterone levels to a similar extent before and after administration of celiprolol.(ABSTRACT TRUNCATED AT 250 WORDS)
为评估塞利洛尔的体液和血流动力学（全身和肾脏）效应，并评估这些效应是否至少部分归因于多巴胺（DA）受体的激活，9例轻度至中度单纯性原发性高血压门诊患者，至少3周未接受任何治疗，按照双盲随机试验模式，分别接受塞利洛尔（每日一次，400毫克）和安慰剂治疗，各为期1个月。在每个治疗期结束时，在给予生理盐水溶液和静脉注射甲氧氯普胺后，测量血压、心率、肾血浆流量、肾小球滤过率、血浆肾素活性、血浆醛固酮和血浆去甲肾上腺素。与安慰剂相比，塞利洛尔显著降低了平均血压、心率和血浆去甲肾上腺素。在塞利洛尔治疗期间，血浆肾素活性呈下降趋势，但与血浆醛固酮的变化无关。尽管平均血压下降，但肾血浆流量未改变，因此肾血管阻力显著降低。肾小球滤过率未变，滤过分数在塞利洛尔治疗期间呈下降趋势。塞利洛尔引起的肾血管阻力和平均血压的下降百分比倾向于与血浆去甲肾上腺素的变化相关。甲氧氯普胺不影响塞利洛尔的血流动力学（全身和肾脏）效应，也不影响血浆肾素活性和血浆去甲肾上腺素，并且在给予塞利洛尔前后，它使醛固酮水平升高的程度相似。（摘要截断于250字）
