Gianoulakis C
Department of Psychiatry, McGill University, Verdun, Québec, Canada.
Alcohol Clin Exp Res. 1987 Dec;11(6):567-73. doi: 10.1111/j.1530-0277.1987.tb00176.x.
Pregnant rats were fed an ethanol diet from the first day of pregnancy until parturition. Control rats were either pair fed with an isocaloric sucrose diet, or fed with standard lab chow (basic control group). Rats fed with the ethanol diet and their pair-fed controls showed a similar increase in body weight during pregnancy, which was lower than the increase observed in the basic control group. At 10 days after ethanol withdrawal all three groups presented similar body weights. A lower body growth was exhibited by the offspring of both the ethanol and the sucrose pair-fed rats, implicating a prenatal nutritional factor on the postnatal growth. Furthermore, the rate of body growth was lower in the offspring of the ethanol-treated animals than in the offspring of both their pair-fed and the basic control rats, indicating the presence of an additional ethanol-associated factor. On day 4 of development, the concentration of beta-endorphin peptides (pmol/mg protein) in the pituitary gland and the anterior lobe, of the offspring of the ethanol-treated animals and their sucrose pair-fed controls, was significantly higher than that of the offspring of the basic control animals. However, a lower content of beta-endorphin-like peptides was noticed in the whole pituitary gland, the anterior lobe, and the intermediate lobe of the offspring of the ethanol-treated rats and their pair-fed controls on days 8, 14, and 22 postnatally.(ABSTRACT TRUNCATED AT 250 WORDS)
怀孕大鼠从怀孕第一天开始直至分娩一直喂食乙醇饮食。对照大鼠要么与等热量蔗糖饮食配对喂食，要么喂食标准实验室饲料（基础对照组）。喂食乙醇饮食的大鼠及其配对喂食的对照组在怀孕期间体重增加情况相似，但低于基础对照组观察到的增加量。乙醇戒断10天后，所有三组大鼠体重相似。乙醇组和蔗糖配对喂食组大鼠的后代均表现出较低的身体生长速度，这表明产前营养因素对产后生长有影响。此外，乙醇处理组动物的后代身体生长速度低于其配对喂食组和基础对照组的后代，这表明存在与乙醇相关的额外因素。在发育第4天，乙醇处理组动物及其蔗糖配对喂食对照组的后代垂体和前叶中β-内啡肽肽（pmol/毫克蛋白质）的浓度显著高于基础对照组动物的后代。然而，在出生后第8天、14天和22天，乙醇处理组大鼠及其配对喂食对照组的后代的整个垂体、前叶和中间叶中β-内啡肽样肽的含量较低。（摘要截短于250字）
