舒芬太尼和阿芬太尼对斯普拉格-道利大鼠的生殖及致畸作用。

Reproductive and teratogenic effects of sufentanil and alfentanil in Sprague-Dawley rats.

作者信息

Fujinaga M, Mazze R I, Jackson E C, Baden J M

机构信息

Department of Anesthesia, Stanford University School of Medicine, California.

出版信息

Anesth Analg. 1988 Feb;67(2):166-9.

PMID:2963565

Abstract

The reproductive and teratogenic effects of sufentanil and alfentanil were studied in a total of 168 Sprague-Dawley rats in two separate experiments. Either sufentanil (10, 50, or 100 micrograms.kg-1.day-1) or alfentanil (8 mg.kg-1.day-1) were administered continuously from day 5 through day 20 of pregnancy using subcutaneously implanted osmotic minipumps. Cesarean sections were performed on day 20 of pregnancy, reproductive indexes were determined, and the 1484 fetuses were examined for external, visceral, and skeletal abnormalities. No significant adverse reproductive or teratogenic effects were observed with either narcotic.

摘要

在两项独立实验中，对总共168只斯普拉格-道利大鼠研究了舒芬太尼和阿芬太尼的生殖及致畸作用。在妊娠第5天至第20天，使用皮下植入的渗透微型泵持续给予舒芬太尼（10、50或100微克·千克⁻¹·天⁻¹）或阿芬太尼（8毫克·千克⁻¹·天⁻¹）。在妊娠第20天进行剖宫产，测定生殖指标，并对1484只胎儿进行外观、内脏和骨骼异常检查。两种麻醉药均未观察到明显的不良生殖或致畸作用。