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血管免疫母细胞性T细胞淋巴瘤：外周T细胞淋巴瘤的一种罕见亚型。

Angioimmunoblastic T-cell lymphoma: a rare subtype of peripheral T-cell lymphoma.

作者信息

Rai Manoj Ponadka, Bedi Prabhjot Singh, Marinas Edwin B, Khan Nazia Naz S

机构信息

Michigan State University/Sparrow hospital B301, 788 Service Road East Lansing Michigan 48824.

UPMC East 2775 Mosside Blvd Monroeville Pennsylvania 15146.

出版信息

Clin Case Rep. 2018 Feb 10;6(4):750-752. doi: 10.1002/ccr3.1388. eCollection 2018 Apr.

DOI:10.1002/ccr3.1388
PMID:29636953
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5889216/
Abstract

Angioimmunoblastic T-cell lymphoma (AITL) is a rare form of NHL and usually presents in the late stage due to the atypical laboratory findings. Immunohistochemistry of the lymph node in AITL is characterized by positive CD2, CD3, CD4, CD10, CXCL-13, PD1 often BCL-6 and CD20 positive. Meshworks of follicular dendritic cells are seen outside follicles with CD21 and CD23 stains. EBV can be often positive as well. Autologous transplantation should be offered in the first remission as poor outcome is reported with anthracycline-containing regimens.

摘要

血管免疫母细胞性T细胞淋巴瘤（AITL）是一种罕见的非霍奇金淋巴瘤（NHL）形式，由于其非典型的实验室检查结果，通常在晚期出现。AITL淋巴结的免疫组织化学特征为CD2、CD3、CD4、CD10、CXCL - 13、PD1通常呈阳性，BCL - 6和CD20也常呈阳性。用CD21和CD23染色可在滤泡外看到滤泡树突状细胞网络。EBV通常也可为阳性。由于含蒽环类药物方案的预后较差，应在首次缓解时提供自体移植。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c0/5889216/b30e935ecc9b/CCR3-6-750-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c0/5889216/080f5971f080/CCR3-6-750-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c0/5889216/262c1832e20e/CCR3-6-750-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c0/5889216/3d4adae6813f/CCR3-6-750-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c0/5889216/b30e935ecc9b/CCR3-6-750-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c0/5889216/080f5971f080/CCR3-6-750-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c0/5889216/262c1832e20e/CCR3-6-750-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c0/5889216/3d4adae6813f/CCR3-6-750-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c0/5889216/b30e935ecc9b/CCR3-6-750-g004.jpg

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本文引用的文献

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2
Angioimmunoblastic T-cell lymphoma: the many-faced lymphoma.血管免疫母细胞性 T 细胞淋巴瘤：多面性淋巴瘤。
Blood. 2017 Mar 2;129(9):1095-1102. doi: 10.1182/blood-2016-09-692541. Epub 2017 Jan 23.
3
The 2016 revision of the World Health Organization classification of lymphoid neoplasms.《世界卫生组织淋巴组织肿瘤分类（2016年修订版）》
Angioimmunoblastic T-cell Lymphoma: An Unusual Case in an Octogenarian.
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Cureus. 2020 Feb 11;12(2):e6956. doi: 10.7759/cureus.6956.
4
Extreme Peripheral Blood Plasmacytosis Mimicking Plasma Cell Leukemia as a Presenting Feature of Angioimmunoblastic T-Cell Lymphoma (AITL).以极端外周血浆细胞增多症模拟浆细胞白血病为表现的血管免疫母细胞性T细胞淋巴瘤（AITL）。
Front Oncol. 2019 Jun 13;9:509. doi: 10.3389/fonc.2019.00509. eCollection 2019.
Blood. 2016 May 19;127(20):2375-90. doi: 10.1182/blood-2016-01-643569. Epub 2016 Mar 15.
4
Clinicopathologic characteristics of angioimmunoblastic T-cell lymphoma: analysis of the international peripheral T-cell lymphoma project.血管免疫母细胞性 T 细胞淋巴瘤的临床病理特征：国际外周 T 细胞淋巴瘤项目分析。
J Clin Oncol. 2013 Jan 10;31(2):240-6. doi: 10.1200/JCO.2011.37.3647. Epub 2012 Aug 6.
5
Angioimmunoblastic T-cell lymphoma: clinical and laboratory features at diagnosis in 77 patients.血管免疫母细胞性T细胞淋巴瘤：77例患者诊断时的临床和实验室特征
Medicine (Baltimore). 2007 Sep;86(5):282-292. doi: 10.1097/MD.0b013e3181573059.