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母细胞性浆细胞样树突状细胞肿瘤

Blastic plasmacytoid dendritic cell neoplasm.

作者信息

Rai Manoj Ponadka, Bedi Prabhjot Singh, Kandola Samanjit Kaur, Kavuturu Shilpa, Singhal Rashi

机构信息

Michigan State University/Sparrow Hospital 788 Service Road, B301 Clinical Center East Lansing Michigan 48824.

UPMC East 2775 Mosside Blvd Monroeville Pennsylvania 15146.

出版信息

Clin Case Rep. 2018 Mar 4;6(4):770-772. doi: 10.1002/ccr3.1457. eCollection 2018 Apr.

DOI:10.1002/ccr3.1457
PMID:29636962
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5889251/
Abstract

Blastic plasmacytoid dendritic cell neoplasm is an aggressive neoplasm with a median survival of only a few months despite treatment. An exhaustive immunohistochemical workup is required to differentiate it from myeloid sarcoma and extranodal NK/T cell lymphoma. Treatment is with induction using a regimen utilized for leukemia. Allogeneic hematopoietic stem cell transplantation is recommended for those who achieve remission following induction.

摘要

母细胞性浆细胞样树突状细胞肿瘤是一种侵袭性肿瘤，尽管接受了治疗，其平均生存期仅为几个月。需要进行详尽的免疫组织化学检查以将其与髓系肉瘤和结外NK/T细胞淋巴瘤相鉴别。治疗采用用于白血病的诱导方案。对于诱导治疗后达到缓解的患者，建议进行异基因造血干细胞移植。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8859/5889251/cebb4345eb58/CCR3-6-770-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8859/5889251/9d9e52662641/CCR3-6-770-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8859/5889251/f8a1b67bceb5/CCR3-6-770-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8859/5889251/36a0323c56b6/CCR3-6-770-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8859/5889251/b8569cf25490/CCR3-6-770-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8859/5889251/a6aa3424b7e7/CCR3-6-770-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8859/5889251/cebb4345eb58/CCR3-6-770-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8859/5889251/9d9e52662641/CCR3-6-770-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8859/5889251/f8a1b67bceb5/CCR3-6-770-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8859/5889251/36a0323c56b6/CCR3-6-770-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8859/5889251/b8569cf25490/CCR3-6-770-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8859/5889251/a6aa3424b7e7/CCR3-6-770-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8859/5889251/cebb4345eb58/CCR3-6-770-g006.jpg

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引用本文的文献

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本文引用的文献

1
Optimized immunohistochemical panel to differentiate myeloid sarcoma from blastic plasmacytoid dendritic cell neoplasm.用于鉴别髓系肉瘤与浆细胞样树突状细胞肿瘤的优化免疫组化组合
Mod Pathol. 2014 Aug;27(8):1137-43. doi: 10.1038/modpathol.2013.238. Epub 2014 Jan 3.
2
Blastic plasmacytoid dendritic cell neoplasm.母细胞性浆细胞样树突状细胞肿瘤
Br J Haematol. 2014 Mar;164(6):757. doi: 10.1111/bjh.12666. Epub 2013 Nov 25.
3
Blastic plasmacytoid dendritic cell neoplasm.母细胞性浆细胞样树突状细胞肿瘤
Blood. 2012 Oct 4;120(14):2784. doi: 10.1182/blood-2012-03-417030.
4
TCL1 and CLA expression in agranular CD4/CD56 hematodermic neoplasms (blastic NK-cell lymphomas) and leukemia cutis.TCL1和CLA在无颗粒CD4/CD56皮肤血液肿瘤（母细胞性NK细胞淋巴瘤）及皮肤白血病中的表达。
Am J Clin Pathol. 2004 Aug;122(2):307-13. doi: 10.1309/0QPP-AVTU-PCV9-UCLV.