Sheng Jiyao, Qin Hanjiao, Zhang Kun, Li Bingjin, Zhang Xuewen
Department of Hepatobiliary and Pancreatic Surgery, The Second Hospital of Jilin UniversityChangchun 130041, Jilin, China.
Department of Radiotherapy, The Second Hospital of Jilin UniversityChangchun 130041, Jilin, China.
Am J Cancer Res. 2018 Mar 1;8(3):354-365. eCollection 2018.
Hepatocellular carcinoma (HCC) is a malignant tumor with poor prognosis. Surgical resection is recommended for very early-stage and early-stage HCC, but HCC is still prone to recurrence and metastasis after surgery. Furthermore, treatment options for intermediate- and advanced-stage HCC are relatively limited. Systemic therapy is the preferred method to kill residual cancer cells after surgery and prolong survival time of inoperable patients, but most cases are insensitive to chemotherapeutic agents, restricting widespread clinical application of systemic therapy. Many studies have found that various chemotherapeutic drugs for HCC treatment can increase autophagic flux of HCC cells, and it may be related with enhancing drug resistance and promoting cell survival. However, enhancement of autophagic flux may also induce tumor cell death in some cases, leading to marked inconsistency across studies. Here we reviewed the mechanisms underlying the increase in autophagic flux in HCC cells induced by chemotherapeutic drugs and examined the contributions of autophagy and related pathways to chemotherapy drug resistance. Our aim was to identify potential autophagy-related targets for improving the sensitivity of HCC to chemotherapeutic drugs.
肝细胞癌（HCC）是一种预后较差的恶性肿瘤。对于极早期和早期HCC，建议进行手术切除，但HCC术后仍易复发和转移。此外，中晚期HCC的治疗选择相对有限。全身治疗是术后杀死残留癌细胞并延长无法手术患者生存时间的首选方法，但大多数病例对化疗药物不敏感，限制了全身治疗的广泛临床应用。许多研究发现，用于治疗HCC的各种化疗药物可增加HCC细胞的自噬通量，这可能与增强耐药性和促进细胞存活有关。然而，在某些情况下，自噬通量的增强也可能诱导肿瘤细胞死亡，导致各研究结果明显不一致。在此，我们综述了化疗药物诱导HCC细胞自噬通量增加的潜在机制，并探讨了自噬及相关信号通路在化疗耐药中的作用。我们的目的是确定潜在的自噬相关靶点，以提高HCC对化疗药物的敏感性。
