Thomas Eliza, Peacock Phil J, Bates Sarah E
Faculty of Health Sciences, University of Bristol, Bristol, UK.
Department of Paediatrics, Great Western Hospital, Swindon, UK.
BMJ Paediatr Open. 2017 Aug 11;1(1):e000060. doi: 10.1136/bmjpo-2017-000060. eCollection 2017.
Depression in pregnancy is commonly treated using selective serotonin reuptake inhibitors (SSRIs). A possible withdrawal syndrome following in utero exposure has been reported, but there is currently no UK guidance on the management of these neonates.
All 160 neonatal units in England were asked for information regarding their management of SSRI-exposed babies.
Responses were obtained from 112/160 (70%) units. Only four units had a specific protocol for managing SSRI-exposed neonates. Twenty-one units (19%) conduct routine observations on exposed neonates, while 37 units (33%) would consider treating babies with signs of withdrawal or toxicity.
Very few neonatal units in England have specific guidelines for the management of babies exposed to SSRIs in utero, with practice varying greatly between units. Further research is needed on the outcomes of SSRI-exposed babies to support development of standardised evidence-based guidelines to ensure all mothers and babies receive similar high-quality care.
孕期抑郁症通常使用选择性5-羟色胺再摄取抑制剂（SSRI）进行治疗。有报道称，子宫内接触过此类药物的新生儿可能会出现戒断综合征，但目前英国尚无针对这些新生儿管理的指南。
向英格兰所有160个新生儿病房询问有关其对接触过SSRI的婴儿的管理信息。
收到了112/160（70%）个病房的回复。只有4个病房有管理接触过SSRI新生儿的具体方案。21个病房（19%）对接触过药物的新生儿进行常规观察，而37个病房（33%）会考虑治疗有戒断或中毒迹象的婴儿。
在英格兰，极少有新生儿病房有针对子宫内接触过SSRI的婴儿的具体管理指南，各病房的做法差异很大。需要对接触过SSRI的婴儿的结局进行进一步研究，以支持制定标准化的循证指南，确保所有母婴都能获得类似的高质量护理。
