[Effect of lithium carbonate on glycolysis in different areas of the rat brain in acute alcoholic intoxication].

Selective activation of phosphofructokinase (PFK) and lactate dehydrogenase (LDG) in the cerebral cortex and an increase of glucose and lactate contents in all other brain areas were noted in acute alcoholic intoxication of rats (2.5 g/kg). Lithium carbonate potentiated the inhibitory action of alcohol on glycolysis in the brain tissue. In combination with ethanol it decreased the activity of PFK and LDG in all studied brain areas and increased glucose and lactate levels.