Kolukisa Mehmet, Soysal Pınar, Gületkin Tuğçe Özdemir, Karatoprak Cumali, Bilgen Halide Rengin, Gürsoy Azize Esra
Bezmialem Vakıf University, Medical Faculty, Department of Neurology, Istanbul, Turkey.
Eylül University, Medical Faculty, Department of Geriatrics, Izmir, Turkey.
Ideggyogy Sz. 2016 Sep 30;69(9-10):356-360. doi: 10.18071/isz.69.0356.
Restless Leg Syndrome (RLS) also known as Willis-Ekbom Disease (WED) is a common condition associated with reduced quality of life and other medical conditions, particularly cardiovascular diseases. Despite its common occurrence, it is widely underdiagnosed and undertreated. Therefore, identification of high-risk individuals for RLS/WED bears diagnostic and therapeutic significance. Iron deficiency anemia has a role in the pathophysiology of RLS/WED and both conditions have been reported to occur higher in females. In this study, the frequency of RLS/WED among women diagnosed with iron deficiency anemia was examined as well as laboratory variables that could guide the clinician in the diagnosis of RLS/WED.
A total of 51 women attending to the department of internal medicine with complaints of fatigue and tiredness and diagnosed as having iron deficiency anemia were evaluated using the International Restless Leg Syndrome Study Group (IRLSSG) diagnostic criteria for RLS. Laboratory variables were recorded. The severity of RLS/WED was assessed using the RLS rating scale in patients diagnosed with RLS/WED.
RLS/WED was diagnosed in 41.1% of the women with iron deficiency anemia. There were no significant differences between women with or without RLS /WED in terms of laboratory variables. Also, no correlations were observed between disease severity and laboratory variables.
There is an 8 to 10-fold increase in the incidence of RLS/WED among women with iron deficiency anemia as compared to general population. Therefore, a possible diagnosis of RLS/WED should be kept in mind in all women with iron deficiency anemia.
不宁腿综合征（RLS）又称威利氏 - 埃克博姆病（WED），是一种常见病症，与生活质量下降及其他疾病相关，尤其是心血管疾病。尽管其发病率高，但普遍存在诊断不足和治疗不足的情况。因此，识别RLS / WED的高危个体具有诊断和治疗意义。缺铁性贫血在RLS / WED的病理生理学中起作用，且据报道这两种病症在女性中更为常见。在本研究中，我们调查了被诊断为缺铁性贫血的女性中RLS / WED的发生率，以及有助于临床医生诊断RLS / WED的实验室指标。
共有51名因疲劳和疲倦主诉到内科就诊且被诊断为缺铁性贫血的女性，按照国际不宁腿综合征研究组（IRLSSG）的RLS诊断标准进行评估。记录实验室指标。对被诊断为RLS / WED的患者，使用RLS评分量表评估RLS / WED的严重程度。
41.1%的缺铁性贫血女性被诊断为RLS / WED。有RLS / WED和无RLS / WED的女性在实验室指标方面无显著差异。此外，未观察到疾病严重程度与实验室指标之间存在相关性。
与普通人群相比，缺铁性贫血女性中RLS / WED的发病率增加了8至10倍。因此，所有缺铁性贫血女性都应考虑可能患有RLS / WED。
