The evaluation of tiodonium chloride as an antiplaque and anticaries agent. III. Evaluation of the antiplaque potential of tiodonium chloride utilizing a rat model.

Tiodonium chloride (4-chlorophenyl-2-thienyliodonium chloride), when used in a twice daily mouthrinse at a concentration of 0.3% for either one or four weeks, inhibited dental plaque formation in rats that had been inoculated with Streptococcus mutans 6715-15 and Actinomyces viscosus T-6. Mouthrinses containing 0.1 and 0.2% tiodonium chloride were also effective in inhibiting plaque, but not as consistently as the 0.3% level.