Department of Chemistry , Emory University , 1515 Dickey Drive , Atlanta , Georgia 30322 , United States.
Org Lett. 2018 Apr 20;20(8):2399-2402. doi: 10.1021/acs.orglett.8b00739. Epub 2018 Apr 11.
Rhodium(II)-catalyzed reactions between isopropyl acetate and trichloroethyl aryldiazoacetates result in the formation of oxirane intermediates that ring open under the reaction conditions to form tertiary alcohols. When the reaction is catalyzed by the dirhodium tetrakis(triarylcyclopropanecarboxylate) complex, Rh( S-2-Cl,4-BrTPCP), the tertiary alcohols are formed with good asymmetric induction (80-88% ee).
铑（II）催化的异丙基乙酸酯和三氯乙基芳基重氮乙酸酯之间的反应导致环氧化物中间体的形成，这些中间体在反应条件下开环形成叔醇。当反应由双铑四（三芳基环丙烷羧酸酯）配合物，Rh（S-2-Cl，4-BrTPCP）催化时，叔醇以良好的不对称诱导（80-88%ee）形成。
