Nemoto Yasuko, Kubota Takehiko, Nohno Kaname, Nezu Arata, Morozumi Toshiya, Yoshie Hiromasa
Int J Periodontics Restorative Dent. 2018 May/Jun;38(3):373-381. doi: 10.11607/prd.3288.
Use of collagen membrane (CM) with deproteinized bovine bone mineral (DBBM) and enamel matrix derivative (EMD) in periodontal regenerative therapy was evaluated. A total of 40 intrabony defects in periodontitis patients were treated. Clinical parameters and filled bone volume (FBV) and rate (FBR) were assessed. Probing pocket depth (PPD) was reduced significantly at 12 months with CM treatment, while clinical attachment level (CAL), FBV, and FBR showed similar improvements. In stratified analyses, CM-treated thick-biotype patients showed significant improvement in PPD and CAL. Regenerative therapy with the use of EMD and DBBM showed similar improvements in periodontal tissue regeneration with or without CM. The combination with CM appeared to influence the healing of soft tissue and was effective in decreasing pocket depth.
评估了胶原膜（CM）联合脱蛋白牛骨矿物质（DBBM）和釉基质衍生物（EMD）在牙周再生治疗中的应用。共治疗了40例牙周炎患者的骨内缺损。评估了临床参数、骨填充体积（FBV）和骨填充率（FBR）。采用CM治疗12个月时，探诊深度（PPD）显著降低，而临床附着水平（CAL）、FBV和FBR也有类似改善。分层分析显示，CM治疗的厚生物型患者PPD和CAL有显著改善。使用EMD和DBBM的再生治疗在有无CM的情况下对牙周组织再生有类似改善。与CM联合使用似乎影响软组织愈合，并有效减少牙周袋深度。
