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连续两代人乙型肝炎垂直传播患病率的评估。

Assessment of the prevalence of vertical hepatitis B transmission in two consecutive generations.

作者信息

Nakano Larissa Akeme, Katayose Jéssica Toshie, Abreu Rodrigo Martins, Mendes Luis Cláudio Alfaia, Martins Maria Cleusa, Pinto Vanusa Barbosa, Carrilho Flair José, Ono Suzane Kioko

机构信息

Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

出版信息

Rev Assoc Med Bras (1992). 2018 Feb;64(2):154-158. doi: 10.1590/1806-9282.64.02.154.

DOI:10.1590/1806-9282.64.02.154
PMID:29641674
Abstract

INTRODUCTION

Hepatitis B is an important public health problem in the world and one of the forms of contagion would be through vertical transmission. Precose diagnosis allows the adoption of prophylaxis measures, which results in prevention in more than 90% of cases.

OBJECTIVE

To describe the prevalences of vertical transmission and compare two generations (mother/patient and patient/child).

METHOD

This was a cross-sectional study, which included 101 patients. The interviews were performed through the application of the instrument of data collection and information of the physical file before the medical consultation.

RESULTS

The mean ± SD of age was 50.9 ± 13.1 years, the male gender predominated, with 56.4% of the patients, and the predominance was white, with 43.6%. Vertical transmission between mother and patient occurred in 17.8% and between patient and child, in 7.9%. In all of the eight cases of vertical transmission, the diagnosis was after the birth of children infected with HBV, and in 3/8 (37.5%), there was more than one case of infection by this mechanism per patient, totaling 13 children with the disease.

CONCLUSION

There was a reduction in vertical transmission, showing that preventive measures were effective.

摘要

引言

乙型肝炎是全球一个重要的公共卫生问题,其传染形式之一是垂直传播。早期诊断有助于采取预防措施,可使超过90%的病例得到预防。

目的

描述垂直传播的患病率,并比较两代人(母亲/患者和患者/子女)的情况。

方法

这是一项横断面研究,纳入了101名患者。访谈通过在医疗咨询前应用数据收集工具和查阅病历信息来进行。

结果

年龄的均值±标准差为50.9±13.1岁,男性占主导,占患者的56.4%,白人占主导,占43.6%。母亲与患者之间的垂直传播发生率为17.8%,患者与子女之间为7.9%。在所有8例垂直传播病例中,诊断均在感染HBV的儿童出生后进行,且在3/8(37.5%)的患者中,每名患者通过这种机制感染的病例不止1例,共有13名儿童患病。

结论

垂直传播有所减少,表明预防措施是有效的。

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