Song Xiaolong, Qu Huiyan, Wang Yong, Yang Tianshu, Rong Jingfeng, Zhou Hua
Department of Cardiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Department of Cardiology, Yancheng Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu 224001, China.
Discov Med. 2018 Mar;25(137):113-130.
Stem cells are a promising solution for the treatment of heart failure due to their ability to repopulate injured myocardium and restore cardiac function. However, many hindrances (such as low survival/viability and integration of transplanted cells, poor homing and cardiac differentiation efficiency, and inadequate cell retention and engraftment) compromise the full regenerative potential provided by stem cells. Therefore, it is necessary to optimize stem cell/progenitor therapy to improve clinical efficacy. By analogy, in order for crops to grow, good seeds are needed. They also need sufficient fertilizer, herbicides, and pesticides to be "optimized." In this review, we provide a comprehensive overview of "seeds" (comparison of stem cell types, different combinations of stem cells, age, size, and dose of stem cells) and "fertilizers" (optimizing stem/progenitor cells and genetic strategies, preconditioning with drugs, and physical changes) for heart failure.
干细胞因其能够重新填充受损心肌并恢复心脏功能，是治疗心力衰竭的一种有前景的解决方案。然而，许多障碍（如移植细胞的低存活率/活力和整合、归巢及心脏分化效率差，以及细胞保留和植入不足）损害了干细胞提供的全部再生潜力。因此，有必要优化干细胞/祖细胞疗法以提高临床疗效。打个比方，为了让作物生长，需要优质种子。它们还需要充足的肥料、除草剂和杀虫剂来进行“优化”。在本综述中，我们全面概述了用于心力衰竭的“种子”（干细胞类型比较、干细胞的不同组合、干细胞的年龄、大小和剂量）和“肥料”（优化干细胞/祖细胞和基因策略、药物预处理以及物理改变）。
