CF-UM-UP (Centre of Physics of University of Minho and Porto), Department of Physics, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal; Centre for the research and Technology of Agro-Environmental and Biological Sciences, CITAB-UM, Department of Biology, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
CF-UM-UP (Centre of Physics of University of Minho and Porto), Department of Physics, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal.
Prog Neurobiol. 2018 Sep;168:21-41. doi: 10.1016/j.pneurobio.2018.04.004. Epub 2018 Apr 8.
Age related neurodegenerative disorders (ARND) are presented as the most debilitating and challenging diseases associated with the central nervous system. Despite the advent of active molecules with a positive role on neurodegenerative mechanisms, many of the current therapeutic strategies remain ineffective in treating or preventing ARND. Lipid nanocarriers have emerged as efficient delivery systems with the capability to cross biological barriers, especially the blood brain barrier (BBB). Also, when associated to natural compounds, lipid nanocarriers have demonstrated to be an interesting alternative to ARND therapies with multiple beneficial effects. This comprehensive review focus on state-of-the-art lipid based nanocarriers for the delivery of natural compounds targeting neurodegeneration. A critical analysis of published reports will be also provided giving indications to researchers about the most promising ARND nanotherapy strategies.
与中枢神经系统相关的年龄相关性神经退行性疾病（ARND）是最具危害性和挑战性的疾病。尽管有许多积极作用于神经退行性机制的活性分子问世，但目前的许多治疗策略在治疗或预防 ARND 方面仍然无效。脂质纳米载体作为有效的递药系统已经出现，具有穿透生物屏障（特别是血脑屏障）的能力。此外，当与天然化合物结合时，脂质纳米载体已被证明是治疗 ARND 的一种有前途的替代方法，具有多种有益作用。本综述重点介绍了用于递运针对神经退行性变的天然化合物的最先进的基于脂质的纳米载体。还对已发表的报告进行了批判性分析，为研究人员提供了有关最有前途的 ARND 纳米治疗策略的指示。
