尼可地尔对清醒犬大冠状动脉的影响。
Effects of nicorandil on large epicardial coronary artery in conscious dogs.
作者信息
Yamada A, Tomoike H, Hayashi Y, Nishijima H, Nakamura M
机构信息
Research Institute of Angiocardiology, Kyushu University, Japan.
出版信息
Arzneimittelforschung. 1987 Nov;37(11):1252-5.
The effect of 2-nicotinamidoethyl nitrate (nicorandil, SG-75, Sigmart) on coronary circulation was studied in conscious dogs, instrumented previously under sterile condition with sonomicrometers for the external coronary diameter measurement, and an electromagnetic flow plobe on the left circumflex coronary artery and a catheter into the thoracic aorta. Intravenous administration of nicorandil in doses of 10, 30, 100 and 300 micrograms/kg increased coronary blood flow dose-relatedly by 13 +/- 2, 24 +/- 3, 144 +/- 18 and 309 +/- 36%, respectively. Nicorandil also increased the diameter of the large epicardial coronary artery by 38 +/- 6, 71 +/- 11, 150 +/- 24 and 173 +/- 26 microns in doses of 10, 30, 100 and 300 micrograms/kg, respectively. To eliminate flow-dependent dilation of the coronary artery, the external diameter of the large epicardial coronary artery was measured during fixing the amount of coronary blood flow constant by a cuff occluder after intravenous administration of nicorandil, however, the degree of coronary diameter increase was not attenuated. Thus, nicorandil dilates both large and small coronary arteries in conscious dogs, the former dilation being independent from changes in coronary blood flow.
在清醒犬中研究了2-烟酰胺基硝酸乙酯（尼可地尔，SG-75，西格玛特）对冠脉循环的影响。这些犬先前在无菌条件下进行了仪器植入，用超声微测仪测量冠状动脉外径，在左旋冠状动脉上安装电磁血流探头，并在胸主动脉插入导管。静脉注射剂量为10、30、100和300微克/千克的尼可地尔，冠状动脉血流量分别剂量依赖性增加13±2%、24±3%、144±18%和309±36%。尼可地尔还分别使大的心外膜冠状动脉直径增加38±6微米、71±11微米、150±24微米和173±26微米，剂量分别为10、30、100和300微克/千克。为消除冠状动脉的流量依赖性扩张，在静脉注射尼可地尔后用袖带阻断器使冠状动脉血流量保持恒定时测量大的心外膜冠状动脉外径，然而，冠状动脉直径增加的程度并未减弱。因此，尼可地尔可使清醒犬的大、小冠状动脉扩张，前者的扩张与冠状动脉血流量变化无关。
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