Wnt信号通路在甲状腺稳态与癌发生中的作用

Ely Kim A, Bischoff Lindsay A, Weiss Vivian L

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Genes (Basel). 2018 Apr 10;9(4):204. doi: 10.3390/genes9040204.

The Wnt pathway is essential for stem cell maintenance, but little is known about its role in thyroid hormone signaling and thyroid stem cell survival and maintenance. In addition, the role of Wnt signaling in thyroid cancer progenitor cells is also unclear. Here, we present emerging evidence for the role of Wnt signaling in somatic thyroid stem cell and thyroid cancer stem cell function. An improved understanding of the role of Wnt signaling in thyroid physiology and carcinogenesis is essential for improving both thyroid disease diagnostics and therapeutics.

Wnt信号通路对于干细胞维持至关重要，但对于其在甲状腺激素信号传导以及甲状腺干细胞存活和维持中的作用却知之甚少。此外，Wnt信号在甲状腺癌祖细胞中的作用也不清楚。在此，我们展示了关于Wnt信号在甲状腺体细胞干细胞和甲状腺癌干细胞功能中作用的新证据。更好地理解Wnt信号在甲状腺生理学和致癌作用中的作用对于改善甲状腺疾病的诊断和治疗至关重要。