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线粒体肿瘤抑制因子1是小鼠子宫中富含AT的互作结构域1A和孕激素受体的一个靶点。

Mitochondrial tumor suppressor 1 is a target of AT-rich interactive domain 1A and progesterone receptor in the murine uterus.

作者信息

Chang Hye Jin, Teasley Hanna E, Yoo Jung-Yoon, Kim Tae Hoon, Jeong Jae-Wook

机构信息

Obstetrics, Gynecology & Reproductive Biology, Michigan State University, Grand Rapids, MI 49503, USA.

Health Promotion Center, Seoul National University Bundang Hospital, Seongnam 132620, Korea.

出版信息

Asian-Australas J Anim Sci. 2018 Aug;31(8):1176-1182. doi: 10.5713/ajas.18.0011. Epub 2018 Apr 12.

DOI:10.5713/ajas.18.0011
PMID:29642667
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6043432/
Abstract

OBJECTIVE

Progesterone receptor (PGR) and AT-rich interactive domain 1A (ARID1A) have important roles in the establishment and maintenance of pregnancy in the uterus. In present studies, we examined the expression of mitochondrial tumor suppressor 1 (MTUS1) in the murine uterus during early pregnancy as well as in response to ovarian steroid hormone treatment.

METHODS

We performed quantitative reverse transcription polymerase chain reaction and immunohistochemistry analysis to investigate the regulation of MTUS1 by ARID1A and determined expression patterns of MTUS1 in the uterus during early pregnancy.

RESULTS

The expression of MTUS1 was detected on day 0.5 of gestation (GD 0.5) and then gradually increased until GD 3.5 in the luminal and glandular epithelium. However, the expression of MTUS1 was significantly reduced in the uterine epithelial cells of Pgrcre/+Arid1af/f and Pgr knockout (PRKO) mice at GD 3.5. Furthermore, MTUS1 expression was remarkably induced after P4 treatment in the luminal and glandular epithelium of the wild-type mice. However, the induction of MTUS1 expression was not detected in uteri of Pgrcre/+Arid1af/f or PRKO mice treated with P4.

CONCLUSION

These results suggest that MTUS1 is a novel target gene by ARID1A and PGR in the uterine epithelial cells.

摘要

目的

孕激素受体（PGR）和富含AT的互作结构域1A（ARID1A）在子宫妊娠的建立和维持中发挥重要作用。在本研究中，我们检测了妊娠早期小鼠子宫中线粒体肿瘤抑制因子1（MTUS1）的表达以及对卵巢甾体激素处理的反应。

方法

我们进行了定量逆转录聚合酶链反应和免疫组织化学分析，以研究ARID1A对MTUS1的调控，并确定MTUS1在妊娠早期子宫中的表达模式。

结果

在妊娠第0.5天（GD 0.5）检测到MTUS1的表达，然后在腔上皮和腺上皮中逐渐增加，直至GD 3.5。然而，在GD 3.5时，Pgrcre/+Arid1af/f和孕激素受体敲除（PRKO）小鼠的子宫上皮细胞中MTUS1的表达显著降低。此外，在野生型小鼠的腔上皮和腺上皮中，孕酮（P4）处理后MTUS1表达明显诱导。然而，在用P4处理的Pgrcre/+Arid1af/f或PRKO小鼠子宫中未检测到MTUS1表达的诱导。

结论

这些结果表明MTUS1是子宫上皮细胞中ARID1A和PGR的一个新的靶基因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8e2/6043432/34f13477e5a6/ajas-31-8-1176f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8e2/6043432/50bc15d152ba/ajas-31-8-1176f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8e2/6043432/875617432219/ajas-31-8-1176f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8e2/6043432/2ba7a111f44a/ajas-31-8-1176f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8e2/6043432/34f13477e5a6/ajas-31-8-1176f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8e2/6043432/50bc15d152ba/ajas-31-8-1176f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8e2/6043432/875617432219/ajas-31-8-1176f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8e2/6043432/2ba7a111f44a/ajas-31-8-1176f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8e2/6043432/34f13477e5a6/ajas-31-8-1176f4.jpg

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Angiotensin II type 2 receptor-interacting protein 3a inhibits ovarian carcinoma metastasis via the extracellular HMGA2-mediated ERK/EMT pathway.血管紧张素II 2型受体相互作用蛋白3a通过细胞外HMGA2介导的ERK/EMT途径抑制卵巢癌转移。
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