Matsumoto Akinobu, Nakayama Keiichi I
Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University.
Cell Struct Funct. 2018 May 18;43(1):75-83. doi: 10.1247/csf.18005. Epub 2018 Apr 11.
Although the definition of a noncoding RNA (ncRNA) is an RNA molecule that does not encode a protein, recent evidence has revealed that some ncRNAs are indeed translated to give rise to small polypeptides (usually containing fewer than 100 amino acids). Despite their small size, however, these peptides are often biologically relevant in that they are required for a variety of cellular processes. In this review, we summarize the production and functions of peptides that have been recently identified as translation products of putative ncRNAs.Key words: long noncoding RNA (lncRNA), circular RNA (circRNA), primary miRNA (pri-miRNA), translation, peptide.
尽管非编码RNA（ncRNA）的定义是一种不编码蛋白质的RNA分子，但最近的证据表明，一些ncRNA确实会被翻译产生小多肽（通常含有少于100个氨基酸）。然而，尽管这些肽的尺寸较小，但它们在生物学上往往具有相关性，因为它们参与多种细胞过程。在本综述中，我们总结了最近被鉴定为假定ncRNA翻译产物的肽的产生和功能。关键词：长链非编码RNA（lncRNA）、环状RNA（circRNA）、初级微小RNA（pri-miRNA）、翻译、肽。
