Biomedicine Research Center, State Key Laboratory of Respiratory Disease, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
Key Laboratory of Protein Modification and Degradation, Guangzhou Medical University, Guangzhou 511436, China.
Mol Ther. 2019 Oct 2;27(10):1718-1725. doi: 10.1016/j.ymthe.2019.09.001. Epub 2019 Sep 6.
Non-coding RNAs (ncRNAs) are unique RNA transcripts that have been widely identified in the eukaryotic genome and have been shown to play key roles in the development of many cancers. However, the rapid development of genome-wide translation profiling and ribosome profiling has revealed that a small number of small open reading frames (sORFs) within ncRNAs actually have peptide- or protein-coding potential. The peptides or proteins encoded by ncRNA (HOXB-AS3, encoded by long ncRNA [lncRNA]; FBXW7-185aa, PINT-87aa, and SHPRH-146aa, encoded by circular RNA [circRNA]; and miPEP-200a and miPEP-200b, encoded by primary miRNAs) have been shown to be critical players in cancer development and progression, through effects upon the regulation of glucose metabolism, the epithelial-to-mesenchymal transition, and the ubiquitination pathway. In this review, we summarize the reported peptides or proteins encoded by ncRNAs in cancer and explore the application of these peptides or proteins in the development of anti-tumor drugs and the identification of relevant therapeutic targets and tumor biomarkers.
非编码 RNA（ncRNA）是在真核基因组中广泛鉴定的独特 RNA 转录物，已被证明在许多癌症的发展中发挥关键作用。然而，全基因组翻译谱和核糖体谱的快速发展表明，ncRNA 内的少数小开放阅读框（sORF）实际上具有肽或蛋白质编码潜力。ncRNA 编码的肽或蛋白（HOXB-AS3，由长 ncRNA [lncRNA]编码；FBXW7-185aa、PINT-87aa 和 SHPRH-146aa，由环状 RNA [circRNA]编码；miPEP-200a 和 miPEP-200b，由初级 miRNA 编码）已被证明通过影响葡萄糖代谢、上皮-间充质转化和泛素化途径的调节，在癌症的发展和进展中发挥关键作用。在这篇综述中，我们总结了 ncRNA 在癌症中编码的报道肽或蛋白，并探讨了这些肽或蛋白在抗肿瘤药物开发和相关治疗靶点和肿瘤生物标志物鉴定中的应用。
