Olczak S A, Fitzgerald M G, Nattrass M, Wright A D
Diabetic Clinic, General Hospital, Birmingham, UK.
Diabet Med. 1988 Jan;5(1):68-9. doi: 10.1111/j.1464-5491.1988.tb00944.x.
Diabetic ketoacidosis (DKA) often presents with hyperkalaemia. We investigated whether it was more likely in patients taking potassium-retaining diuretics. A retrospective survey of all patients (552 cases) presenting in DKA between 1974 and 1984 was undertaken. Initial biochemical data were compared for patients recorded as taking potassium-retaining diuretics (7 cases) at the time of presentation with those taking potassium-losing diuretics (13 cases), and age matched control groups were selected from those who presented in DKA but were not taking diuretics. There was no significant difference in initial serum potassium levels between the diuretic treated groups. The serum sodium was higher in the control group than in the potassium losing group (p = 0.045) and the serum urea significantly lower (p = 0.045). We conclude that potassium-retaining diuretics do not predispose to hyperkalaemia in diabetic ketoacidosis.
糖尿病酮症酸中毒（DKA）常伴有高钾血症。我们研究了服用保钾利尿剂的患者发生高钾血症的可能性是否更高。对1974年至1984年间所有出现DKA的患者（552例）进行了回顾性调查。将就诊时记录为服用保钾利尿剂的患者（7例）与服用排钾利尿剂的患者（13例）的初始生化数据进行比较，并从出现DKA但未服用利尿剂的患者中选取年龄匹配的对照组。利尿剂治疗组之间的初始血清钾水平无显著差异。对照组的血清钠高于排钾组（p = 0.045），血清尿素显著低于排钾组（p = 0.045）。我们得出结论，保钾利尿剂不会使糖尿病酮症酸中毒患者更易发生高钾血症。
