[北京石景山区中老年人群慢性牙周炎与颈动脉内膜中层厚度的相关性研究]

[Association between chronic periodontitis and carotid intima-media thickness of middle-aged and older adults in Shijingshan community of Beijing].

作者信息

Liu Y, Luan Q X

机构信息

Department of General Dentistry II, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Department of Periodontology, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

出版信息

Beijing Da Xue Xue Bao Yi Xue Ban. 2018 Apr 18;50(2):264-270.

PMID:29643525

Abstract

OBJECTIVE

To investigate the relationship between periodontal disease and subclinical atherosclerosis in middle-aged and older adults in Shijingshan community of Beijing.

METHODS

In 2005-2010, a total of 830 middle-aged and older adults were recruited from Shijingshan community of Beijing, who were divided into two groups by severity of periodontitis. A questionnaire, periodontal examination, blood biochemical examination, carotid intima-media thickness (CIMT), including common carotid artery (CCA-IMT), internal carotid artery (ICA-IMT) and carotid bifurcation (CB-IMT), were measured of each subject. The associations of periodontitis with CIMT was evaluated by multivariable Logistic regression analysis and analysis of covariance, adjusted for age, gender, education level, hypertension, hyperlipidemia, obesity, smoking, drinking, and diabetes. And then anther definition of periodontitis (mild periodontitis: percentage of AL≥3 mm <10%; moderate periodontitis: percentage of AL≥3 mm 10%-30%; severe periodontitis: percentage of AL≥3 mm ≥30%) was used to investigate the hypotheses that different classification of periodontitis would affect results.

RESULTS

The subjects with moderate-severe periodontitis were characterized by significantly higher levels of CCA-IMT, ICA-IMT, CB-IMT and mean CIMT than the mild group. In the univariate analysis, moderate-severe periodontitis was associated with an increased risk of ICA-IMT>0.9 mm (adjusted OR=1.230, 95% CI: 1.058-1.452, P=0.031). Furthermore, moderate periodontitis was associated with an increased risk of CB-IMT>0.9 mm (adjusted OR: 1.297, 95%CI: 1.117-1.753, P=0.011) and severe periodontitis was associated with an increased risk of CB-IMT>0.9 mm (adjusted OR=1.771, 95%CI: 1.176-3.503, P=0.042) according to another classification of periodontitis.

CONCLUSION

Our data provided evidence that periodontitis was associated with CIMT among middle-aged and older adults in Shijingshan community of Beijing and different periodontitis classification would affect the results.

摘要

目的

探讨北京市石景山区社区中老年人群牙周病与亚临床动脉粥样硬化之间的关系。

方法

2005年至2010年，从北京市石景山区社区招募了830名中老年人群，根据牙周炎严重程度将其分为两组。对每位受试者进行问卷调查、牙周检查、血液生化检查、测量颈动脉内膜中层厚度（CIMT），包括颈总动脉（CCA-IMT）、颈内动脉（ICA-IMT）和颈动脉分叉处（CB-IMT）。采用多变量Logistic回归分析和协方差分析评估牙周炎与CIMT的关联，并对年龄、性别、教育程度、高血压、高脂血症、肥胖、吸烟、饮酒和糖尿病进行校正。然后采用另一种牙周炎定义（轻度牙周炎：附着丧失（AL）≥3mm的百分比<10%；中度牙周炎：AL≥3mm的百分比为10%-30%；重度牙周炎：AL≥3mm的百分比≥30%）来研究不同牙周炎分类是否会影响结果的假设。

结果

中重度牙周炎患者的CCA-IMT、ICA-IMT、CB-IMT和平均CIMT水平显著高于轻度组。在单因素分析中，中重度牙周炎与ICA-IMT>0.9mm风险增加相关（校正OR=1.230，95%CI：1.058-1.452，P=0.031）。此外，根据另一种牙周炎分类，中度牙周炎与CB-IMT>0.9mm风险增加相关（校正OR：1.297，95%CI：1.117-1.753，P=0.011），重度牙周炎与CB-IMT>0.9mm风险增加相关（校正OR=1.771，95%CI：1.176-3.503，P=0.042）。