Iqbal Khalida, Islam Najmul, Azam Iqbal, Mehboobali Naseema, Iqbal Mohammad Perwaiz
Khalida Iqbal, Department of Biological & Biomedical Sciences, Aga Khan University, Karachi, Pakistan.
Najmul Islam, Department of Medicine, Aga Khan University, Karachi, Pakistan.
Pak J Med Sci. 2018 Jan-Feb;34(1):204-208. doi: 10.12669/pjms.341.11977.
To investigate the relationship of statins (drug given to reduce serum levels of LDL-cholesterol) on vitamin D levels of Pakistani type 2 diabetes mellitus (DM) patients in a hospital in Karachi.
In a cross-sectional survey, 312 consecutive patients with type 2 DM (219 males and 93 females, age 22-70 years) were recruited with informed consent. A questionnaire was administered to find out whether they were statin users or non-users. Serum was analyzed for concentrations of 25(OH) vitamin D [25(OH)D] and other related biomarkers such as serum cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, phosphate and calcium using kit methods. Multiple Linear Regression was used to evaluate association of statin use with serum levels of vitamin D while adjusting for related covariates including duration of statin use, duration of type 2 DM and smoking.
Mean concentrations of serum cholesterol, and LDL-cholesterol were lower among statin users compared to statin non-users ( < 0.01), while HDL-cholesterol levels were higher (<0.01). No relationship was observed between statin use and serum levels of vitamin D (=0.768), when adjusted for age, gender, BMI, duration of type 2 DM, smoking, serum cholesterol and LDL-cholesterol. The adjusted regression coefficient (β) and standard error [SE(β)] for statin use duration were 0.012 (0.042), when serum levels of vitamin D was taken as an outcome.
Lack of association was found between statin use and vitamin D levels in a hospital-based population of Pakistani patients with type 2 DM.
在卡拉奇一家医院中，研究他汀类药物（用于降低血清低密度脂蛋白胆固醇水平的药物）与巴基斯坦2型糖尿病（DM）患者维生素D水平之间的关系。
在一项横断面调查中，经知情同意招募了312例连续的2型糖尿病患者（219例男性和93例女性，年龄22 - 70岁）。发放问卷以了解他们是否为他汀类药物使用者或非使用者。使用试剂盒方法分析血清中25(OH)维生素D [25(OH)D]以及其他相关生物标志物的浓度，如血清胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、磷酸盐和钙。在调整包括他汀类药物使用时长、2型糖尿病病程和吸烟等相关协变量的情况下，采用多元线性回归评估他汀类药物使用与维生素D血清水平之间的关联。
与非他汀类药物使用者相比，他汀类药物使用者的血清胆固醇和低密度脂蛋白胆固醇平均浓度较低（<0.01），而高密度脂蛋白胆固醇水平较高（<0.01）。在调整年龄、性别、体重指数、2型糖尿病病程、吸烟、血清胆固醇和低密度脂蛋白胆固醇后，未观察到他汀类药物使用与维生素D血清水平之间存在关联（=0.768）。以维生素D血清水平为结果时，他汀类药物使用时长的调整回归系数（β）和标准误[SE(β)]为0.012（0.042）。
在以医院为基础的巴基斯坦2型糖尿病患者群体中，未发现他汀类药物使用与维生素D水平之间存在关联。
