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经导管主动脉瓣置换术后瓣中瓣植入后通过四维计算机断层扫描检测到的瓣膜血栓形成的病理证实

Pathologic confirmation of valve thrombosis detected by four-dimensional computed tomography following valve-in-valve transcatheter aortic valve replacement.

作者信息

Gopal Ambarish, Ribeiro Nathalia, Squiers John J, Holper Elizabeth M, Black Michael, Gopal Deepika, Szerlip Molly, Harrington Katherine B, Potluri Srinivas, DiMaio J Michael, Brown David L, Grayburn Paul A, Mack Michael J, Brinkman William T

机构信息

The Heart Hospital Baylor Plano, 4716 Alliance Blvd, Suite 340, Plano, TX 75093, USA.

出版信息

Glob Cardiol Sci Pract. 2017 Jun 30;2017(2):15. doi: 10.21542/gcsp.2017.15.

DOI:10.21542/gcsp.2017.15
PMID:29644227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5871399/
Abstract

A major concern regarding transcatheter aortic valve replacement (TAVR) is leaflet thrombosis. Four-dimensional computed tomography (4D-CT) is the preferred imaging modality to evaluate patients with suspected valve thrombosis. To date, the abnormal findings visualized by 4D-CT suggestive of leaflet thrombosis have lacked pathologic confirmation from a surgically explanted valve in a surviving patient. Herein, we provide pathologic confirmation of thrombus formation following surgical explantation of a thrombosed TAVR prosthesis that was initially identified by 4D-CT.

摘要

经导管主动脉瓣置换术(TAVR)的一个主要问题是瓣叶血栓形成。四维计算机断层扫描(4D-CT)是评估疑似瓣膜血栓形成患者的首选成像方式。迄今为止,4D-CT显示的提示瓣叶血栓形成的异常发现,尚未得到存活患者手术取出瓣膜的病理证实。在此,我们提供了一例经手术取出的血栓形成的TAVR假体的病理证实,该假体最初是通过4D-CT识别的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4742/5871399/76a70b5a8948/gcsp-2017-2-e201715-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4742/5871399/76a70b5a8948/gcsp-2017-2-e201715-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4742/5871399/76a70b5a8948/gcsp-2017-2-e201715-g001.jpg

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本文引用的文献

1
Subclinical leaflet thrombosis in surgical and transcatheter bioprosthetic aortic valves: an observational study.外科和经导管生物瓣主动脉瓣中的亚临床瓣叶血栓形成:一项观察性研究。
Lancet. 2017 Jun 17;389(10087):2383-2392. doi: 10.1016/S0140-6736(17)30757-2. Epub 2017 Mar 19.
2
Transcatheter Aortic Valve Thrombosis: Incidence, Predisposing Factors, and Clinical Implications.经导管主动脉瓣血栓形成:发生率、易患因素及临床意义。
J Am Coll Cardiol. 2016 Nov 8;68(19):2059-2069. doi: 10.1016/j.jacc.2016.08.010. Epub 2016 Aug 28.
3
Shedding More Light on Valve Thrombosis After Transcatheter Aortic Valve Replacement.
经导管主动脉瓣置换术后瓣膜血栓形成的更多解读
J Am Coll Cardiol. 2016 Feb 16;67(6):656-658. doi: 10.1016/j.jacc.2015.11.046.
4
Incidence, Timing, and Predictors of Valve Hemodynamic Deterioration After Transcatheter Aortic Valve Replacement: Multicenter Registry.经导管主动脉瓣置换术后瓣叶血流动力学恶化的发生率、时间和预测因素:多中心注册研究。
J Am Coll Cardiol. 2016 Feb 16;67(6):644-655. doi: 10.1016/j.jacc.2015.10.097.
5
Possible Subclinical Leaflet Thrombosis in Bioprosthetic Aortic Valves.生物瓣主动脉瓣叶可能存在亚临床血栓。
N Engl J Med. 2015 Nov 19;373(21):2015-24. doi: 10.1056/NEJMoa1509233. Epub 2015 Oct 5.
6
Thrombus formation following transcatheter aortic valve replacement.经导管主动脉瓣置换术后血栓形成。
JACC Cardiovasc Interv. 2015 Apr 27;8(5):728-39. doi: 10.1016/j.jcin.2015.03.005.