乙酰化 PET 作为诊断肝脂肪变性的工具。

[C]acetate PET as a tool for diagnosis of liver steatosis.

机构信息

Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Division of General and Pediatric Radiology, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.

出版信息

Abdom Radiol (NY). 2018 Nov;43(11):2963-2969. doi: 10.1007/s00261-018-1558-4.

DOI:10.1007/s00261-018-1558-4

PMID:29644441

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6208816/

Abstract

PURPOSE

To investigate [C]acetate PET-surrogate parameter of fatty acid synthase activity-as suitable tool for diagnosis and monitoring of liver steatosis.

METHODS

In this retrospective study, data were obtained from 83 prostatic carcinoma patients from 1/2008 to 1/2014. Mean HU was calculated from unenhanced CT of all patients from liver with liver HU less than 40 as threshold for liver steatosis. SUV of the liver and of the blood pool in thoracic aorta (as background for calculation of a liver/background ratio [SUV]) was measured. t test was used with a P < 0.05 considered as statistically significant difference and ROC analysis was used for calculating specificity and sensitivity.

RESULTS

19/83 patients (20%) had diagnosis of hepatic steatosis according to CT. Uptake of [C]acetate was significantly higher in patients with hepatic steatosis as compared to control group (SUV 7.96 ± 2.0 vs. 5.48 ± 2.3 [P < 0.001]). There was also a significant correlation between both SUV (r = - 0.52, P < 0.001) and SUV (r = - 0.59, P < 0.001) with the density (HU) of the liver. In ROC analysis for detection of liver steatosis SUV (threshold: 5.86) had a sensitivity of 94% and specificity of 69% with an AUC of 0.81. Increasing body mass index is correlated with the severity of steatosis.

CONCLUSION

We showed for the first time that hepatic steatosis associates with increased [C]acetate uptake. Also, severity of steatosis correlates with [C]acetate uptake. [C]acetate uptake PET seems promising for the assessment of liver steatosis.

摘要

目的

研究[C]乙酸盐作为脂肪酸合酶活性的正电子发射断层扫描（PET）替代参数，作为诊断和监测肝脂肪变性的合适工具。

方法

在这项回顾性研究中，数据来自 2008 年 1 月至 2014 年 1 月的 83 例前列腺癌患者。从所有患者的未增强 CT 中计算肝脏的平均 HU 值，以肝脏 HU 值小于 40 作为肝脂肪变性的阈值。测量肝脏和胸主动脉血液池的 SUV（作为计算肝脏/背景比 [SUV] 的背景）。使用 t 检验，P 值小于 0.05 被认为具有统计学意义差异，ROC 分析用于计算特异性和敏感性。

结果

根据 CT，83 例患者中有 19 例（20%）诊断为肝脂肪变性。与对照组相比，患有肝脂肪变性的患者[C]乙酸盐摄取明显更高（SUV 7.96±2.0 与 5.48±2.3 [P<0.001]）。SUV 与肝脏密度（HU）之间也存在显著相关性（r=-0.52，P<0.001）和 SUV 与肝脏密度（r=-0.59，P<0.001）。在检测肝脂肪变性的 ROC 分析中，SUV（阈值：5.86）的敏感性为 94%，特异性为 69%，AUC 为 0.81。体重指数的增加与脂肪变性的严重程度相关。