State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
National Engineering Research Center for Advanced Polymer Processing Technologies, Zhengzhou University, Zhengzhou, China.
Angew Chem Int Ed Engl. 2018 May 28;57(22):6475-6479. doi: 10.1002/anie.201801462. Epub 2018 May 2.
Although helical nanofibrous structures have great influence on cell adhesion, the role played by chiral molecules in these structures on cells behavior has usually been ignored. The chirality of helical nanofibers is inverted by the odd-even effect of methylene units from homochiral l-phenylalanine derivative during assembly. An increase in cell adhesion on left-handed nanofibers and weak influence of cell behaviors on right-handed nanofibers are observed, even though both were derived from l-phenylalanine derivatives. Weak and negative influences on cell behavior was also observed for left- and right-handed nanofibers derived from d-phenylalanine, respectively. The effect on cell adhesion of single chiral molecules and helical nanofibers may be mutually offset.
尽管螺旋纳米纤维结构对细胞黏附具有重要影响，但手性分子在这些结构中对细胞行为的作用通常被忽视。在组装过程中，手性 l-苯丙氨酸衍生物的亚甲基单元奇偶效应使螺旋纳米纤维的手性发生反转。尽管均来自 l-苯丙氨酸衍生物，但观察到细胞在左手性纳米纤维上的黏附增加，而右手性纳米纤维对细胞行为的影响较弱。来自 d-苯丙氨酸的左手性和右手性纳米纤维对细胞行为的影响也较弱且为负性。单个手性分子和螺旋纳米纤维对细胞黏附的影响可能相互抵消。
