Kloosterman A, Frankena K
Department of Animal Husbandry, Agricultural University, Wageningen, The Netherlands.
Vet Parasitol. 1988 Jan;26(3-4):305-20. doi: 10.1016/0304-4017(88)90099-4.
Interactions between gastrointestinal worms (Ostertagia ostertagi, Cooperia oncophora) and lungworms (Dictyocaulus viviparus) in calves were studied by assessing the effect of primary infections with either group of worms on the development of homologous or heterologous challenge infections. Primary infections with lungworms resulted in some degree of resistance to challenge with gastrointestinal worms, but this resistance was lower than that found after homologous infection. Primary infections with gastrointestinal worms did not confer any resistance to challenge with lungworms. On the contrary, an indication was found of some enhancing effect of previous gastrointestinal worm infection on the establishment of lungworms. The highest degree of resistance against lungworm challenge was found where calves have been primarily infected with lungworms. Lungworm infections produced some elevation of serum pepsinogen levels. Gastrointestinal worms evoked a rise in circulating eosinophils, although this rise was smaller and occurred later than in lungworm-infected calves. Under the conditions of the experiment, the effect of 6000 infective lungworm larvae on weight gain was larger than the effect of 100,000 L3 of Ostertagia ostertagi and 100,000 L3 of Cooperia oncophora.
通过评估一组蠕虫的初次感染对同源或异源攻击感染发展的影响，研究了犊牛体内胃肠蠕虫（奥斯特他线虫、柯氏圆线虫）与肺线虫（胎生网尾线虫）之间的相互作用。肺线虫的初次感染导致对胃肠蠕虫攻击有一定程度的抵抗力，但这种抵抗力低于同源感染后的抵抗力。胃肠蠕虫的初次感染并未赋予对肺线虫攻击的任何抵抗力。相反，发现先前胃肠蠕虫感染对肺线虫的建立有某种增强作用。在犊牛最初感染肺线虫的情况下，发现对肺线虫攻击的抵抗力最强。肺线虫感染使血清胃蛋白酶原水平有所升高。胃肠蠕虫引起循环嗜酸性粒细胞增多，尽管这种增多比感染肺线虫的犊牛小且出现得晚。在实验条件下，6000条感染性肺线虫幼虫对体重增加的影响大于100000条奥斯特他线虫L3幼虫和100000条柯氏圆线虫L3幼虫的影响。
