Yatham L N, McHale P A, Kinsella A
St. Ita's Hospital, Portrane, Dublin, Republic of Ireland.
Acta Psychiatr Scand. 1988 Jan;77(1):38-41. doi: 10.1111/j.1600-0447.1988.tb05074.x.
The purpose of this study was to ascertain the frequency of Alzheimer's dementia in the relatives of Down's probands and to establish whether these two disorders cluster together. Out of 128 families of Down's probands, only 67 responded to the questionnaire. Twelve cases of Alzheimer's dementia were found in the eight families of 67 probands. There was a significant increase in the frequency of presenile dementia, but no significant increase in senile dementia among the first and second degree relatives of these probands. The methodological problems were discussed and future directions suggested.
本研究的目的是确定唐氏综合征先证者亲属中阿尔茨海默病性痴呆的发生率，并确定这两种疾病是否聚集在一起。在128个唐氏综合征先证者家庭中，只有67个家庭回复了问卷。在67个先证者的8个家庭中发现了12例阿尔茨海默病性痴呆。这些先证者的一级和二级亲属中早老性痴呆的发生率显著增加，但老年性痴呆的发生率没有显著增加。文中讨论了方法学问题并提出了未来的研究方向。
