Maloberti Alessandro, Farina Francesca, Carbonaro Marco, Piccinelli Enrico, Bassi Ilaria, Pansera Francesco, Grassi Guido, Mancia Giuseppe, Palestini Paola, Giannattasio Cristina
a Cardiology IV, "A.De Gasperis" Department , Ospedale Niguarda Ca' Granda , Milan , Italy.
b School of Medicine and Surgery , Milano-Bicocca University , Milan , Italy.
Blood Press. 2018 Oct;27(5):262-270. doi: 10.1080/08037051.2018.1461010. Epub 2018 Apr 12.
Only few studies evaluated biomarkers useful for defining the cardiovascular risk of a subject in a pre-clinical condition (i.e. healthy subjects). In this context we sought to determine the relationships of Plasminogen activator inhibitor type 1 (PAI-1), P-Selectin, Tissue Inhibitors Metalloproteinases type 1 (TIMP-1) and Cystatin-C with subclinical Target Organ Damage (TOD) in normotensive and normoglycemic subjects without known cardiovascular and kidney diseases.
480 blood donors participated at the present analysis. TOD was evaluated as Pulse Wave Velocity (PWV), Left Ventricular Hypertrophy (LVH) and Intima Media Thickness (IMT) and carotid plaque presence) grouped together under carotid TOD.
3.1% of the subjects showed a PWV higher than 10 m/sec with those subjects exerting significantly lower values of P-Selectine (0.068 ± 0.015 vs 0.08 ± 0.036 mg/L, p = .014). 8.8% of the subjects showed carotid TOD that was associated with higher Cystatin-C values (0.67 ± 0.17 vs 0.63 ± 0.14 mg/L, p = .045). Finally 23.8% of the subjects showed LVH with no significant differences regarding biomarkers. Despite some significant correlations between biomarkers and TOD, at the multivariate analysis none came out to be as significant predictor of the assessed TOD.
in normotensive and normoglycemic healthy subjects, the evaluated biomarkers of atherosclerotic process didn't show any significant association with cardiac, carotid and vascular TOD while age and BP are its principal predictors.
仅有少数研究评估了可用于界定处于临床前状态（即健康受试者）的个体心血管风险的生物标志物。在此背景下，我们试图确定纤溶酶原激活物抑制剂1（PAI-1）、P-选择素、金属蛋白酶组织抑制因子1（TIMP-1）和胱抑素C与无已知心血管和肾脏疾病的血压正常及血糖正常受试者的亚临床靶器官损害（TOD）之间的关系。
480名献血者参与了本分析。TOD被评估为脉搏波速度（PWV）、左心室肥厚（LVH）和内膜中层厚度（IMT）以及颈动脉斑块的存在情况），它们被归为颈动脉TOD。
3.1%的受试者PWV高于10米/秒，这些受试者的P-选择素值显著较低（0.068±0.015对0.08±0.036毫克/升，p = 0.014）。8.8%的受试者显示有颈动脉TOD，这与较高的胱抑素C值相关（0.67±0.17对0.63±0.14毫克/升，p = 0.045）。最后，23.8%的受试者显示有LVH，生物标志物方面无显著差异。尽管生物标志物与TOD之间存在一些显著相关性，但在多变量分析中，没有一个生物标志物成为所评估TOD的显著预测因子。
在血压正常及血糖正常的健康受试者中，所评估的动脉粥样硬化过程生物标志物与心脏、颈动脉和血管TOD未显示出任何显著关联，而年龄和血压是其主要预测因子。
