Cegielska-Perun Krystyna, Marczuk Ewa, Bujalska-Zadrozny Magdalena
Acta Pol Pharm. 2016 Jul;73(4):843-849.
Leukotrienes (LTs) belong to pro-inflammatory mediators that are biosynthesized from arachidonic acid (AA), inter alia, by 5-lipoxygenase (5-LOX) enzyme in association with 5-LOX-activating protein (FLAP). An activation of LTs synthesis pathway occurs during the development and maintenance of numerous diseases such as asthma, anaphylactic shock, allergic rhinitis, psoriasis, rheumatoid arthritis, osteoporosis, as well as cardiovascular diseases, neurodegenerative diseases and certain types of cancer. The main goal of this review was to present recent advances on the new compounds influencing the LOX pathway, which are under-going clinical studies. The mechanisms of action and possible implementations of these molecules in a treatment of asthma, cancer and cardiovascular diseases are discussed.
白三烯（LTs）属于促炎介质，它主要由花生四烯酸（AA）通过5-脂氧合酶（5-LOX）与5-脂氧合酶激活蛋白（FLAP）联合生物合成。在许多疾病的发生和发展过程中，如哮喘、过敏性休克、过敏性鼻炎、银屑病、类风湿性关节炎、骨质疏松症以及心血管疾病、神经退行性疾病和某些类型的癌症，白三烯合成途径会被激活。本综述的主要目的是介绍正在进行临床研究的、影响脂氧合酶途径的新型化合物的最新进展。讨论了这些分子在哮喘、癌症和心血管疾病治疗中的作用机制和可能的应用。
