Kryzhanovskiĭ G N, Bakuleva L P, Luzina N L, Vinogradov V A, Iarygin K N
Biull Eksp Biol Med. 1988 Feb;105(2):148-50.
Beta-endorphin-like immunoreactivity was studied in 7 patients with algomenorrhea during pain attack and 15 minutes after alpha-tocopherol administration with a therapeutic aim (till the analgetic effect was reached). There was an increase in beta-endorphin-like immunoreactivity after alpha-tocopherol administration. Naloxone administration to 9 patients with algomenorrhea of various etiology resumed the pain. The effect of alpha-tocopherol application for pain relief depended on the pathogenesis of algomenorrhea. At the same time naloxone administration failed to resume the pain in patients, in whom alpha-tocopherol had a strong analgetic effect. It is assumed that the endogenous opioid system participates in alpha-tocopherol effect on pain relief in patients with algomenorrhea.
对7例痛经发作期患者以及15例为治疗目的（直至达到镇痛效果）服用α-生育酚15分钟后的痛经患者进行了β-内啡肽样免疫反应性研究。服用α-生育酚后，β-内啡肽样免疫反应性有所增加。对9例不同病因的痛经患者给予纳洛酮后疼痛复发。α-生育酚用于缓解疼痛的效果取决于痛经的发病机制。与此同时，在α-生育酚具有强烈镇痛作用的患者中，给予纳洛酮未能使疼痛复发。据推测，内源性阿片系统参与了α-生育酚对痛经患者疼痛缓解的作用。
