血液净化治疗对维持性血液透析患者继发性甲状旁腺功能亢进症的影响。
Effect of Hybrid Blood Purification Treatment on Secondary Hyperparathyroidism for Maintenance Hemodialysis Patients.
出版信息
Blood Purif. 2018;46(1):19-26. doi: 10.1159/000486844. Epub 2018 Apr 12.
OBJECTIVE
This study aims to investigate the effects of hybrid blood purification treatment on secondary hyperparathyroidism for maintenance hemodialysis (HD) patients.
METHODS
A total of 40 patients were randomly divided into 2 groups: HD combined with hemoperfusion (HD + HP) group (n = 20) and HD group (n = 20). Changes in intact parathyroid hormone (iPTH) in these 2 groups were compared before and after treatment, and iPTH levels in the HD + HP group were monitored before and after treatment.
RESULTS
iPTH, β2 microglobulin (β2-MG), and cystatin C (CysC) levels were significantly lower in the HD + HP group than in the HD group (p < 0.05), iPTH levels were significantly higher than at the first day after treatment (p < 0.05), and iPTH level was significantly higher (p < 0.05).
CONCLUSION
The clearance effects of HD + HP on iPTH, β2-MG, and CysC are better than HD alone. Treatment with HD + HP every 2 weeks is recommended for maintenance HD patients.
目的
本研究旨在探讨血液灌流联合血液透析（HD）治疗对维持性血液透析（HD）患者继发性甲状旁腺功能亢进症的影响。
方法
将 40 例患者随机分为 2 组：HD 联合血液灌流（HD+HP）组（n=20）和 HD 组（n=20）。比较治疗前后两组患者全段甲状旁腺激素（iPTH）的变化，并监测 HD+HP 组治疗前后 iPTH 水平。
结果
HD+HP 组 iPTH、β2 微球蛋白（β2-MG）和胱抑素 C（CysC）水平明显低于 HD 组（p<0.05），治疗后第 1 天 iPTH 水平明显高于治疗后第 1 天（p<0.05），且 iPTH 水平明显高于（p<0.05）。
结论
HD+HP 对 iPTH、β2-MG 和 CysC 的清除效果优于单纯 HD。建议每周治疗 2 次 HD+HP 治疗维持性 HD 患者。
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