Arnold P A, Guglielmo B J, Hollander H
Department of Pharmacy Services, Good Samaritan Medical Center, Phoenix, AZ 85006.
Drug Intell Clin Pharm. 1988 Jan;22(1):43-5. doi: 10.1177/106002808802200110.
A patient with acquired immunodeficiency syndrome (AIDS) developed rash, fever, neutropenia, and elevated liver function tests during an initial course of trimethoprim-sulfamethoxazole (TMP-SMX) therapy. Upon reexposure to the drug, the patient experienced a severe anaphylactoid reaction associated with pulmonary edema and rhabdomyolysis. Reactions associated with TMP-SMX rechallenge in this patient population have been previously reported but have not been associated with this degree of severity. TMP-SMX therapy should be instituted with extreme caution in patients with AIDS who have demonstrated a prior hypersensitivity reaction to the drug.
