Anti-PD1 associated fulminant myocarditis after a single pembrolizumab dose: the role of occult pre-existing autoimmunity.
作者信息
Martinez-Calle Nicolas, Rodriguez-Otero Paula, Villar Sara, Mejías Luis, Melero Ignacio, Prosper Felipe, Marinello Patricia, Paiva Bruno, Idoate Miguel, San-Miguel Jesus
机构信息
Hematology Department. Clínica Universidad de Navarra, Spain
Instituto de Investigación Sanitaria de Navarra (IDISNA), Pamplona Spain.
出版信息
Haematologica. 2018 Jul;103(7):e318-e321. doi: 10.3324/haematol.2017.185777. Epub 2018 Apr 12.
Abstract
摘要
相似文献
1
Anti-PD1 associated fulminant myocarditis after a single pembrolizumab dose: the role of occult pre-existing autoimmunity.单次帕博利珠单抗给药后出现的抗程序性死亡蛋白1（Anti-PD1）相关暴发性心肌炎：隐匿性自身免疫病的作用
Haematologica. 2018 Jul;103(7):e318-e321. doi: 10.3324/haematol.2017.185777. Epub 2018 Apr 12.
2
Atrophic exocrine pancreatic insufficiency associated with anti-PD1 therapy.与抗PD1治疗相关的萎缩性外分泌胰腺功能不全
Ann Oncol. 2017 Feb 1;28(2):434-435. doi: 10.1093/annonc/mdw626.
3
Complete Atrioventricular Block Associated with Pembrolizumab-induced Acute Myocarditis: The Need for Close Cardiac Monitoring.帕博利珠单抗诱导的急性心肌炎相关的完全性房室传导阻滞：密切心脏监测的必要性
Intern Med. 2018 Nov 1;57(21):3157-3162. doi: 10.2169/internalmedicine.0255-17. Epub 2018 Jun 6.
4
Pulmonary sarcoidosis induced by the anti-PD1 monoclonal antibody pembrolizumab.抗程序性死亡蛋白1（PD1）单克隆抗体帕博利珠单抗诱发的肺结节病
Ann Oncol. 2016 Jun;27(6):1178-1179. doi: 10.1093/annonc/mdw125. Epub 2016 Apr 18.
5
Alemtuzumab for Immune-Related Myocarditis Due to PD-1 Therapy.阿仑单抗治疗因PD-1治疗引起的免疫相关性心肌炎。
N Engl J Med. 2019 Jun 13;380(24):2375-2376. doi: 10.1056/NEJMc1903064.
6
[Pembrolizumab for the treatment of melanoma: updates and perspectives.].[帕博利珠单抗治疗黑色素瘤：最新进展与展望。]
Recenti Prog Med. 2017 Dec;108(12):528-531. doi: 10.1701/2829.28585.
7
Autologous graft-versus-host disease with combined immune checkpoint blockade.联合免疫检查点阻断的自体移植物抗宿主病
Eur J Cancer. 2018 Sep;101:275-277. doi: 10.1016/j.ejca.2018.05.016. Epub 2018 Jul 13.
8
Autoimmune-Related Primary Hypoparathyroidism Possibly Induced by the Administration of Pembrolizumab: A Case Report.帕博利珠单抗给药可能诱发的自身免疫性相关原发性甲状旁腺功能减退症：一例报告
J Oncol Pract. 2018 Jul;14(7):449-451. doi: 10.1200/JOP.18.00076. Epub 2018 Jun 15.
9
Autoimmune Polyarthritis Induced by Cancer Immunotherapy With Checkpoint Inhibitor.由检查点抑制剂癌症免疫疗法诱导的自身免疫性多关节炎
J Clin Rheumatol. 2017 Jun;23(4):235. doi: 10.1097/RHU.0000000000000525.
10
Severe ophthalmoplegia and myocarditis following the administration of pembrolizumab.帕博利珠单抗给药后出现严重眼肌麻痹和心肌炎。
Eur J Cancer. 2018 Mar;91:171-173. doi: 10.1016/j.ejca.2017.11.026. Epub 2017 Dec 26.
引用本文的文献
1
Unmasking the Rare but Lethal Cardiac Complications of Immune Checkpoint Inhibitor Therapy: A Review of Mechanisms, Risk Factors, and Management Strategies.揭示免疫检查点抑制剂治疗罕见但致命的心脏并发症：机制、危险因素及管理策略综述
Curr Treat Options Oncol. 2025 May 24. doi: 10.1007/s11864-025-01329-1.
2
The role of immune checkpoints PD-1 and CTLA-4 in cardiovascular complications leading to heart failure.免疫检查点蛋白PD-1和CTLA-4在导致心力衰竭的心血管并发症中的作用。
Front Immunol. 2025 Apr 4;16:1561968. doi: 10.3389/fimmu.2025.1561968. eCollection 2025.
3
MLKL-Mediated Necroptosis Predominantly Contributes to Immune-Associated Myocardial Damage.混合谱系激酶结构域样蛋白介导的坏死性凋亡主要促成免疫相关的心肌损伤。
Inflammation. 2025 Apr 7. doi: 10.1007/s10753-025-02298-1.
4
The Good (Tumor Killing) and the Bad (Cardiovascular Complications) of Immunologic Checkpoint Inhibitors.免疫检查点抑制剂的益处（肿瘤杀伤）与弊端（心血管并发症）
Curr Cardiol Rep. 2024 Dec;26(12):1487-1498. doi: 10.1007/s11886-024-02147-x. Epub 2024 Oct 23.
5
Steroid-Refractory Myocarditis Induced by Immune Checkpoint Inhibitor Responded to Infliximab: Report of Two Cases and Literature Review.免疫检查点抑制剂诱发的类固醇难治性心肌炎对英夫利昔单抗治疗有效：两例病例报告及文献复习。
Cardiovasc Toxicol. 2024 Nov;24(11):1174-1191. doi: 10.1007/s12012-024-09918-6. Epub 2024 Sep 10.
6
Advances and clinical applications of immune checkpoint inhibitors in hematological malignancies.免疫检查点抑制剂在血液系统恶性肿瘤中的研究进展及临床应用
Cancer Commun (Lond). 2024 Sep;44(9):1071-1097. doi: 10.1002/cac2.12587. Epub 2024 Jul 28.
7
Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti-PD-1 Immune Checkpoint Inhibitor Cancer Therapy.携带人 HLA-DQ8 的鼠 MHC 缺陷非肥胖型糖尿病小鼠对 PD-1 免疫检查点抑制剂癌症治疗产生严重心肌炎和肌炎。
J Immunol. 2024 Apr 15;212(8):1287-1306. doi: 10.4049/jimmunol.2300841.
8
Uncovering the flip side of immune checkpoint inhibitors: a comprehensive review of immune-related adverse events and predictive biomarkers.揭示免疫检查点抑制剂的另一面：免疫相关不良事件及预测生物标志物的全面综述。
Int J Biol Sci. 2024 Jan 1;20(2):621-642. doi: 10.7150/ijbs.89376. eCollection 2024.
9
Immune Checkpoint Inhibitors and Their Cardiovascular Adverse Effects.免疫检查点抑制剂及其心血管不良反应。
Oncol Rev. 2023 Nov 17;17:11456. doi: 10.3389/or.2023.11456. eCollection 2023.
10
Immune checkpoint inhibitor-associated myocarditis: a systematic analysis of case reports.免疫检查点抑制剂相关心肌炎：病例报告的系统分析。
Front Immunol. 2023 Oct 9;14:1275254. doi: 10.3389/fimmu.2023.1275254. eCollection 2023.
本文引用的文献
1
Pembrolizumab, pomalidomide, and low-dose dexamethasone for relapsed/refractory multiple myeloma.帕博利珠单抗、泊马度胺和低剂量地塞米松治疗复发/难治性多发性骨髓瘤。
Blood. 2017 Sep 7;130(10):1189-1197. doi: 10.1182/blood-2017-03-775122. Epub 2017 May 1.
2
Fulminant Myocarditis with Combination Immune Checkpoint Blockade.暴发性心肌炎合并免疫检查点阻断治疗
N Engl J Med. 2016 Nov 3;375(18):1749-1755. doi: 10.1056/NEJMoa1609214.
3
Acute Lymphocytic Myocarditis With Anti-PD-1 Antibody Nivolumab.伴有抗程序性死亡蛋白1（PD-1）抗体纳武单抗的急性淋巴细胞性心肌炎
Circ Heart Fail. 2016 Oct;9(10). doi: 10.1161/CIRCHEARTFAILURE.116.003514.
4
Management of Adverse Events Following Treatment With Anti-Programmed Death-1 Agents.抗程序性死亡-1药物治疗后不良事件的管理
Oncologist. 2016 Oct;21(10):1230-1240. doi: 10.1634/theoncologist.2016-0055. Epub 2016 Jul 8.
5
Acute rhabdomyolysis with severe polymyositis following ipilimumab-nivolumab treatment in a cancer patient with elevated anti-striated muscle antibody.癌症患者横纹肌溶解症伴重度多发性肌炎，抗横纹肌抗体升高，接受伊匹单抗-纳武单抗治疗后
J Immunother Cancer. 2016 Jun 21;4:36. doi: 10.1186/s40425-016-0139-8. eCollection 2016.
6
Immune-related adverse events with immune checkpoint blockade: a comprehensive review.免疫检查点阻断相关的免疫相关不良事件：一项全面综述。
Eur J Cancer. 2016 Feb;54:139-148. doi: 10.1016/j.ejca.2015.11.016. Epub 2016 Jan 5.
7
Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma.免疫检查点抑制剂治疗转移性黑色素瘤致自身免疫性心肌炎并发急性心力衰竭
J Immunother Cancer. 2015 Apr 21;3:11. doi: 10.1186/s40425-015-0057-1. eCollection 2015.
8
PD-L1/PD-1 presence in the tumor microenvironment and activity of PD-1 blockade in multiple myeloma.肿瘤微环境中PD-L1/PD-1的存在及PD-1阻断在多发性骨髓瘤中的活性
Leukemia. 2015 Oct;29(10):2110-3. doi: 10.1038/leu.2015.79. Epub 2015 Mar 17.
9
Programmed death receptor-1/programmed death receptor ligand-1 blockade after transient lymphodepletion to treat myeloma.短暂性淋巴清除后程序性死亡受体-1/程序性死亡受体配体-1 阻断治疗骨髓瘤。
J Immunol. 2013 Jun 1;190(11):5620-8. doi: 10.4049/jimmunol.1202005. Epub 2013 Apr 24.
10
Influenza myocarditis and myositis: case presentation and review of the literature.流感性心肌炎和肌炎：病例报告及文献复习。
Can J Cardiol. 2011 Jul-Aug;27(4):514-22. doi: 10.1016/j.cjca.2011.03.005. Epub 2011 Jun 8.
Zotero 插件