Teranaka Ryotaro, Takiguchi Nobuhiro, Ikeda Atsushi, Souda Hiroaki, Tonooka Toru, Hoshino Isamu, Nabeya Yoshihiro
Division of Esophagus Gastroenterological Surgery, Chiba Cancer Center.
Gan To Kagaku Ryoho. 2018 Mar;45(3):551-553.
The common type carcinoma of gastric cancer is divided into 3 groups, papillary adenocarcinoma(pap), well differentiated tubular adenocarcinoma(tub1)and moderately tubular adenocarcinoma(tub2). In this study, we tried to individualize treatments of them by evaluating their clinicopathological features.
Examined resected specimens were collected from 2000 to 2016. We compared among pap, tub1, and tub2 as the clincopathological features retrospectively.
Histological diagnosis was confirmed to 55 cases with pap, 639 cases with tub1 and 718 cases with tub2. Comparing the ratio of lymph node metastasis(LNM)according to the depth of invasion, tub2 and pap show higher incidence of LNM than tub1 in T1b, T2, and T4(a+b). Tub2 and pap patients have larger number of LNM and worse 5 year survival rates than tub1 patients.
We demonstrated that tub2 and pap may have higher malignancy and show earlier LNM than tub1. When we consider of endoscopic treatment, individualizataing tub1, tub2 and pap is important.
胃癌的常见类型癌分为3组，即乳头状腺癌（pap）、高分化管状腺癌（tub1）和中分化管状腺癌（tub2）。在本研究中，我们试图通过评估它们的临床病理特征来实现个体化治疗。
收集2000年至2016年的手术切除标本。我们回顾性比较了pap、tub1和tub2的临床病理特征。
组织学诊断确诊为pap 55例、tub1 639例、tub2 718例。根据浸润深度比较淋巴结转移（LNM）率，在T1b、T2和T4（a + b）期，tub2和pap的LNM发生率高于tub1。tub2和pap患者的LNM数量更多，5年生存率比tub1患者更差。
我们证明tub2和pap可能具有更高的恶性程度，并且比tub1更早出现LNM。当考虑内镜治疗时，区分tub1、tub2和pap进行个体化治疗很重要。
