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STAT1、IGF1、RAC1 和 MDM2 与骨巨细胞瘤的复发相关。

STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone.

机构信息

Department of Orthopedic Surgery, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou 515041, China.

Department of Pathology, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou 515041, China.

出版信息

J Immunol Res. 2018 Jan 31;2018:4564328. doi: 10.1155/2018/4564328. eCollection 2018.

DOI:10.1155/2018/4564328
PMID:29651441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5831922/
Abstract

BACKGROUND

In our previous study, mouse double minute 2 homolog (MDM2), insulin-like growth factor 1 (IGF1), signal transducer and activator of transcription 1 (STAT1), and Rac family small GTPase 1 (RAC1) were correlated with the recurrence of giant cell tumor of bone (GCT). The aim of this study is to use a large cohort study to confirm the involvement of these four genes in GCT recurrence.

METHODS

The expression of these four genes was detected and compared between GCT patients with or without recurrence. The correlation between the expression of these four genes and clinical characteristics was evaluated. Protein-protein interaction (PPI) network was constructed for functional enrichment analysis.

RESULTS

It showed that the expression levels of MDM2, IGF1, STAT1, and RAC1 in GCT patients with recurrence were significantly higher than those in GCT patients without recurrence ( < 0.05). Multivariate logistic regression analysis suggested that several clinical characteristics may influence prognosis. A PPI network was constructed using the four genes as hub genes. Functional enrichment analysis showed that this network involves many important biological progress mediated by these four genes, including immune response.

CONCLUSION

MDM2, IGF1, STAT1, and RAC1 are associated with GCT recurrence, which might serve as biomarkers for GCT recurrence.

摘要

背景

在我们之前的研究中，鼠双微基因 2 同源物（MDM2）、胰岛素样生长因子 1（IGF1）、信号转导和转录激活因子 1（STAT1）和 Rac 家族小 GTP 酶 1（RAC1）与骨巨细胞瘤（GCT）的复发相关。本研究旨在使用大样本队列研究来证实这四个基因与 GCT 复发的关系。

方法

检测并比较了有或无复发的 GCT 患者中这四个基因的表达情况。评估了这四个基因的表达与临床特征之间的相关性。构建蛋白质-蛋白质相互作用（PPI）网络进行功能富集分析。

结果

结果显示，复发的 GCT 患者中 MDM2、IGF1、STAT1 和 RAC1 的表达水平明显高于无复发的 GCT 患者（<0.05）。多因素 logistic 回归分析提示，一些临床特征可能影响预后。使用这四个基因作为枢纽基因构建了一个 PPI 网络。功能富集分析表明，该网络涉及到许多由这四个基因介导的重要生物学进程，包括免疫反应。

结论

MDM2、IGF1、STAT1 和 RAC1 与 GCT 的复发相关，可能作为 GCT 复发的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a6/5831922/f12ec7e284c4/JIR2018-4564328.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a6/5831922/9e43d373f7c8/JIR2018-4564328.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a6/5831922/71d1e8ff537e/JIR2018-4564328.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a6/5831922/f12ec7e284c4/JIR2018-4564328.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a6/5831922/9e43d373f7c8/JIR2018-4564328.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a6/5831922/71d1e8ff537e/JIR2018-4564328.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a6/5831922/f12ec7e284c4/JIR2018-4564328.003.jpg

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1
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Clin Orthop Relat Res. 2017 Dec;475(12):3071-3081. doi: 10.1007/s11999-017-5451-1. Epub 2017 Jul 19.
2
Fludarabine inhibits STAT1-mediated up-regulation of caspase-3 expression in dexamethasone-induced osteoblasts apoptosis and slows the progression of steroid-induced avascular necrosis of the femoral head in rats.氟达拉滨可抑制地塞米松诱导的成骨细胞凋亡过程中STAT1介导的半胱天冬酶-3表达上调，并减缓大鼠激素性股骨头缺血性坏死的进展。
Apoptosis. 2017 Aug;22(8):1001-1012. doi: 10.1007/s10495-017-1383-1.
3
评估不同原发性骨肿瘤患者肿瘤组织中IGF-1R的局部表达模式以及血液中IGF-1、IGFBP-1和IGFBP-3的循环水平。
Front Oncol. 2023 Jan 13;12:1096438. doi: 10.3389/fonc.2022.1096438. eCollection 2022.
4
Intratumoral immune heterogeneity of prostate cancer characterized by typing and hub genes.肿瘤内前列腺癌免疫异质性的特征在于分型和枢纽基因。
J Cell Mol Med. 2023 Jan;27(1):101-112. doi: 10.1111/jcmm.17641. Epub 2022 Dec 16.
5
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Cell Cycle. 2022 Sep;21(18):1980-1995. doi: 10.1080/15384101.2022.2078614. Epub 2022 May 31.
6
State of the Art and New Concepts in Giant Cell Tumor of Bone: Imaging Features and Tumor Characteristics.骨巨细胞瘤的现状与新概念：影像学特征及肿瘤特性
Cancers (Basel). 2021 Dec 15;13(24):6298. doi: 10.3390/cancers13246298.
Bre Enhances Osteoblastic Differentiation by Promoting the Mdm2-Mediated Degradation of p53.
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Stem Cells. 2017 Jul;35(7):1760-1772. doi: 10.1002/stem.2620. Epub 2017 Apr 24.
4
Autocrine IGF1 Signaling Mediates Pancreatic Tumor Cell Dormancy in the Absence of Oncogenic Drivers.自分泌胰岛素样生长因子1信号在无致癌驱动因素的情况下介导胰腺肿瘤细胞休眠。
Cell Rep. 2017 Feb 28;18(9):2243-2255. doi: 10.1016/j.celrep.2017.02.013.
5
Emerging Role of MDM2 as Target for Anti-Cancer Therapy: A Review.MDM2作为抗癌治疗靶点的新作用：综述
Ann Clin Lab Sci. 2016 Dec;46(6):627-634.
6
Emerging roles of RAC1 in treating lung cancer patients.RAC1在肺癌患者治疗中的新作用。
Clin Genet. 2017 Apr;91(4):520-528. doi: 10.1111/cge.12908. Epub 2016 Nov 24.
7
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Arch Oral Biol. 2017 Jan;73:142-150. doi: 10.1016/j.archoralbio.2016.10.010. Epub 2016 Oct 15.
8
Glucocorticoid-induced osteoporosis: pathophysiological role of GH/IGF-I and PTH/VITAMIN D axes, treatment options and guidelines.糖皮质激素性骨质疏松症：GH/IGF-I 和 PTH/VITAMIN D 轴的病理生理学作用、治疗选择和指南。
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9
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10
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J Cell Mol Med. 2016 Sep;20(9):1611-9. doi: 10.1111/jcmm.12852. Epub 2016 May 25.