Department of Orthopedic Surgery, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou 515041, China.
Department of Pathology, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou 515041, China.
J Immunol Res. 2018 Jan 31;2018:4564328. doi: 10.1155/2018/4564328. eCollection 2018.
In our previous study, mouse double minute 2 homolog (MDM2), insulin-like growth factor 1 (IGF1), signal transducer and activator of transcription 1 (STAT1), and Rac family small GTPase 1 (RAC1) were correlated with the recurrence of giant cell tumor of bone (GCT). The aim of this study is to use a large cohort study to confirm the involvement of these four genes in GCT recurrence.
The expression of these four genes was detected and compared between GCT patients with or without recurrence. The correlation between the expression of these four genes and clinical characteristics was evaluated. Protein-protein interaction (PPI) network was constructed for functional enrichment analysis.
It showed that the expression levels of MDM2, IGF1, STAT1, and RAC1 in GCT patients with recurrence were significantly higher than those in GCT patients without recurrence ( < 0.05). Multivariate logistic regression analysis suggested that several clinical characteristics may influence prognosis. A PPI network was constructed using the four genes as hub genes. Functional enrichment analysis showed that this network involves many important biological progress mediated by these four genes, including immune response.
MDM2, IGF1, STAT1, and RAC1 are associated with GCT recurrence, which might serve as biomarkers for GCT recurrence.
在我们之前的研究中，鼠双微基因 2 同源物（MDM2）、胰岛素样生长因子 1（IGF1）、信号转导和转录激活因子 1（STAT1）和 Rac 家族小 GTP 酶 1（RAC1）与骨巨细胞瘤（GCT）的复发相关。本研究旨在使用大样本队列研究来证实这四个基因与 GCT 复发的关系。
检测并比较了有或无复发的 GCT 患者中这四个基因的表达情况。评估了这四个基因的表达与临床特征之间的相关性。构建蛋白质-蛋白质相互作用（PPI）网络进行功能富集分析。
结果显示，复发的 GCT 患者中 MDM2、IGF1、STAT1 和 RAC1 的表达水平明显高于无复发的 GCT 患者（<0.05）。多因素 logistic 回归分析提示，一些临床特征可能影响预后。使用这四个基因作为枢纽基因构建了一个 PPI 网络。功能富集分析表明，该网络涉及到许多由这四个基因介导的重要生物学进程，包括免疫反应。
MDM2、IGF1、STAT1 和 RAC1 与 GCT 的复发相关，可能作为 GCT 复发的生物标志物。
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