钯催化酚类和丙烯酸酯通过直接脱氢C(sp)-O交叉偶联实现的需氧区域和立体选择性烯烃化反应。
Palladium-catalyzed aerobic regio- and stereo-selective olefination reactions of phenols and acrylates via direct dehydrogenative C(sp)-O cross-coupling.
作者信息
Wu Yun-Bin, Xie Dan, Zang Zhong-Lin, Zhou Cheng-He, Cai Gui-Xin
机构信息
Key Laboratory of Applied Chemistry of Chongqing Municipality, Institute of Bioorganic & Medicinal Chemistry, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
出版信息
Chem Commun (Camb). 2018 Apr 26;54(35):4437-4440. doi: 10.1039/c8cc01226a.
An efficient olefination protocol for the oxidative dehydrogenation of phenols and acrylates has been achieved using a palladium catalyst and O2 as the sole oxidant. This reaction exhibits high regio- and stereo-selectivity (E-isomers) with moderate to excellent isolated yields and a wide substrate scope (32 examples) including ethyl vinyl ketone and endofolliculina.
使用钯催化剂和氧气作为唯一氧化剂，实现了一种用于酚类和丙烯酸酯氧化脱氢的高效烯烃化反应方案。该反应具有高区域选择性和立体选择性（E-异构体），分离产率适中至优异，底物范围广泛（32个实例），包括乙烯基乙基酮和卵泡内菌属。
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