Petrović Vladimir, Šeguljev Zorica, Ristić Mioljub, Djekić-Malbaša Jelena, Radosavljević Biljana, Medić Deana, Mihajlović-Ukropina Mira, Hadnadjev Mirjana, Gajic Ina, Opavski Nataša
Srp Arh Celok Lek. 2016 Sep-Oct;144(9-10):521-6.
Streptococcus pneumoniae is the most common causative agent of bacterial pneumonia and meningitis. Mandatory childhood immunization against pneumococcal diseases is introduced in the new Law on Protection of Population against Communicable Diseases in Serbia.
The objective of this study was to determine the prevalence of pneumococcal serotype distribution in Vojvodina region before routine use of pneumococcal conjugate vaccine in Serbia.
A total of 105 isolates of Streptococcus pneumoniae were collected in the period from January 2009 to April 2016. Based on the results of serotyping in the National Reference Laboratory, we analyzed distribution of circulating serotypes and coverage of conjugate and 23-valent polysaccharide pneumococcal vaccines in different age groups.
Among 105 isolates, a total of 21 different serotypes of Streptococcus pneumoniae were determined. The most frequent serotypes were 3 (21.9%), 19F (20.0%), and 14 (10.5%). The serotype coverage of pneumococcal conjugate vaccines (PCV7, PCV10, and PCV13) was 48.6%, 54.3%, and 84.8%, respectively, while pneumococcal polysaccharide vaccine (PPV23) covered 89.5% of the total number of isolates in all age groups. Serotypes included in PCV7, PCV10, and PCV13 represented 72.0%, 76.0%, and 88.0% of the total number of isolates in children ≤5 years, respectively. Vaccine serotype coverage of PCV13 and PPV23 ranged from 87.1% to 90.3% in adults 50–64 years of age, and 77.8% to 85.2% in adults ≥65 years old.
Serotype distribution of Streptococcus pneumoniae in the population fairly overlaps with the serotypes contained in pneumococcal vaccines, so that implementation of childhood immunization is justified. The study was done in the Province of Vojvodina but the findings may be applied to Serbia as a whole.
肺炎链球菌是细菌性肺炎和脑膜炎最常见的病原体。塞尔维亚新的《预防传染病保护民众法》引入了强制性儿童肺炎球菌疾病免疫接种。
本研究的目的是确定在塞尔维亚常规使用肺炎球菌结合疫苗之前伏伊伏丁那地区肺炎球菌血清型分布的患病率。
2009年1月至2016年4月期间共收集了105株肺炎链球菌分离株。根据国家参考实验室的血清分型结果，我们分析了不同年龄组中循环血清型的分布以及结合疫苗和23价肺炎球菌多糖疫苗的覆盖率。
在105株分离株中，共确定了21种不同的肺炎链球菌血清型。最常见的血清型为3型（21.9%）、19F型（20.0%）和14型（10.5%）。肺炎球菌结合疫苗（PCV7、PCV10和PCV13）的血清型覆盖率分别为48.6%、54.3%和84.8%，而肺炎球菌多糖疫苗（PPV23）覆盖了所有年龄组分离株总数的89.5%。PCV7、PCV10和PCV13中包含的血清型分别占≤5岁儿童分离株总数的72.0%、76.0%和88.0%。PCV13和PPV23在50 - 64岁成年人中的疫苗血清型覆盖率为87.1%至90.3%，在≥65岁成年人中为77.8%至85.2%。
人群中肺炎链球菌的血清型分布与肺炎球菌疫苗中包含的血清型相当重叠，因此实施儿童免疫接种是合理的。该研究在伏伊伏丁那省进行，但研究结果可能适用于整个塞尔维亚。
