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发育过程中慢适应性I型机械感受器患病率的选择性下降。

Selective decline in the prevalence of slowly adapting type I mechanoreceptors during development.

作者信息

Cahusac Peter M B, Senok Solomon

机构信息

Department of Psychology, Stirling University, Stirling FK9 4LA, Scotland, UK; College of Medicine, Alfaisal University, PO Box 50927, Riyadh 11533, Saudi Arabia; Department of Comparative Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.

Department of Psychology, Stirling University, Stirling FK9 4LA, Scotland, UK; Ajman University School of Medicine, PO Box 346, Ajman, UAE.

出版信息

Int J Dev Neurosci. 2018 Aug;68:35-38. doi: 10.1016/j.ijdevneu.2018.04.001. Epub 2018 Apr 10.

DOI:10.1016/j.ijdevneu.2018.04.001
PMID:29653151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6053600/
Abstract

Merkel nerve endings are identified physiologically as slowly adapting type I mechanoreceptor units. They are important for fine acuity tactile perception. We examined the effect of age on the electrophysiological availability of different types of slowly adapting mechanoreceptor units. Using 6-50 week old rats, we observed an obvious decline with age in the probability of recording from St I units of the deep vibrissal nerve. The precipitous decline occurred between ages 6-14 weeks and then stabilized. By contrast, the prevalence of St II units, the other type of slowly adapting mechanoreceptor, remained constant over the age range studied. These observations correlate with anatomical findings reported elsewhere.

摘要

默克尔神经末梢在生理上被识别为慢适应性I型机械感受器单位。它们对于敏锐的触觉感知很重要。我们研究了年龄对不同类型慢适应性机械感受器单位电生理可用性的影响。使用6至50周龄的大鼠,我们观察到随着年龄的增长,从深部触须神经的St I单位记录的概率明显下降。这种急剧下降发生在6至14周龄之间,然后趋于稳定。相比之下,另一种慢适应性机械感受器St II单位的患病率在所研究的年龄范围内保持不变。这些观察结果与其他地方报道的解剖学发现相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1479/6053600/728e22c2750a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1479/6053600/4edfa8fac338/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1479/6053600/728e22c2750a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1479/6053600/4edfa8fac338/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1479/6053600/728e22c2750a/gr2.jpg

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本文引用的文献

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Changes in the axon terminals of primary afferents from a single vibrissa in the rat trigeminal nuclei after active touch deprivation or exposure to an enriched environment.触须剥夺或暴露于丰富环境后,大鼠三叉神经核中来自单一触须的初级传入轴突末梢的变化。
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Merkel cells transduce and encode tactile stimuli to drive Aβ-afferent impulses.默克尔细胞传递和编码触觉刺激,以驱动 Aβ传入冲动。
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Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors.
表皮 Merkel 细胞是机械敏感细胞,可调节哺乳动物的触觉感受器。
Nature. 2014 May 29;509(7502):617-21. doi: 10.1038/nature13250. Epub 2014 Apr 6.
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A pharmacological study of slowly adapting mechanoreceptors responsive to cold thermal stimulation.对冷温度刺激有反应的慢适应性机械感受器的药理学研究。
Neuroscience. 2007 Aug 24;148(2):489-500. doi: 10.1016/j.neuroscience.2007.06.018. Epub 2007 Aug 1.
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NT3 expressed in skin causes enhancement of SA1 sensory neurons that leads to postnatal enhancement of Merkel cells.皮肤中表达的神经营养因子3(NT3)会导致SA1感觉神经元增强,进而使默克尔细胞在出生后增多。
J Comp Neurol. 2004 Apr 5;471(3):352-60. doi: 10.1002/cne.20041.
8
THE EFFECTS OF AN ENRICHED ENVIRONMENT ON THE HISTOLOGY OF THE RAT CEREBRAL CORTEX.丰富环境对大鼠大脑皮质组织学的影响。
J Comp Neurol. 1964 Aug;123:111-20. doi: 10.1002/cne.901230110.
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Friedrich Sigmund Merkel and his "Merkel cell", morphology, development, and physiology: review and new results.弗里德里希·西格蒙德·默克尔及其“默克尔细胞”:形态学、发育与生理学——综述及新成果
Anat Rec A Discov Mol Cell Evol Biol. 2003 Mar;271(1):225-39. doi: 10.1002/ar.a.10029.
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The roles and functions of cutaneous mechanoreceptors.皮肤机械感受器的作用和功能。
Curr Opin Neurobiol. 2001 Aug;11(4):455-61. doi: 10.1016/s0959-4388(00)00234-8.