Department of Clinical Psychology and Psychotherapy, University of Bern, Fabrikstrasse 8, 3012, Bern, Switzerland.
Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
BMC Psychiatry. 2018 Apr 13;18(1):102. doi: 10.1186/s12888-018-1644-8.
Evidence shows that internet-based self-help interventions are effective in reducing symptoms for a wide range of mental disorders. To date, online interventions treating psychotic disorders have been scarce, even though psychosis is among the most burdensome disorders worldwide. Furthermore, the implementation of cognitive-behavioral therapy (CBT) for psychosis in routine health care is challenging. Internet-based interventions could narrow this treatment gap. Thus, a comprehensive CBT-based online self-help intervention for people with psychosis has been developed. The aim of this study is the evaluation of the feasibility and efficacy of the intervention compared with a waiting list control group.
The intervention includes modules on delusion, voice hearing, social competence, mindfulness, and seven other domains. Participants are guided through the program by a personal moderator. Usage can be amended by an optional smartphone app. In this randomized controlled trial, participants are allocated to a waiting list or an intervention of eight weeks. Change in positive psychotic symptoms of both groups will be compared (primary outcome) and predictors of treatment effects will be assessed.
To our knowledge, this project is one of the first large-scale investigations of an internet-based intervention for people with psychosis. It may thus be a further step to broaden treatment options for people suffering from this disorder.
NCT02974400 (clinicaltrials.gov), date of registration: November 28th 2016.
有证据表明，基于互联网的自助干预措施对于多种精神障碍的症状减轻都具有显著效果。迄今为止，针对精神障碍的在线干预措施仍然很少，尽管精神疾病是全球负担最重的疾病之一。此外，在常规医疗保健中实施针对精神疾病的认知行为疗法（CBT）也具有挑战性。基于互联网的干预措施可能会缩小这种治疗差距。因此，已经为精神疾病患者开发了一种综合性的基于 CBT 的在线自助干预措施。本研究的目的是评估该干预措施与等待名单对照组相比的可行性和疗效。
该干预措施包括妄想、幻听、社会能力、正念和其他七个领域的模块。参与者由个人主持人引导完成整个方案。可以通过可选的智能手机应用程序来修改使用情况。在这项随机对照试验中，参与者被分配到等待名单或为期八周的干预组。将比较两组的阳性精神病症状变化（主要结局），并评估治疗效果的预测因素。
据我们所知，该项目是针对精神疾病患者的基于互联网的干预措施的首批大规模研究之一。因此，它可能是为患有这种疾病的人拓宽治疗选择的又一步。
NCT02974400（clinicaltrials.gov），注册日期：2016 年 11 月 28 日。
