甲基苯丙胺类似物α-苄基-N-甲基苯乙胺（ABNMP）的行为效应：酮色林和对氯苯丙氨酸（PCPA）的抑制作用。

Behavioral effects of alpha-benzyl-N-methylphenethylamine (ABNMP), a methamphetamine analog: inhibition by ketanserin and para-chlorophenylalanine (PCPA).

作者信息

Cadet J L, Clark C R, Fahn S

机构信息

Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032.

出版信息

Pharmacol Biochem Behav. 1988 Jan;29(1):125-8. doi: 10.1016/0091-3057(88)90284-5.

DOI:10.1016/0091-3057(88)90284-5

PMID:2965394

Abstract

Acute administration of alpha-benzyl-N-methylphenethylamine (ABNMP) induces lateral heavings, straub tail, backward locomotion, and hindlimb abduction-which are all components of the serotonin (5-HT) syndrome. Ketanserin, a 5-HT-2 receptor antagonist and pretreatment with the 5-HT neurotoxin parachlorophenylalanine (PCPA) attenuated the manifestation of these behavioral abnormalities. These results suggest that ABNMP may cause an acute release of 5-HT similar to that elicited by para-chloroamphetamine.

摘要

急性给予α-苄基-N-甲基苯乙胺（ABNMP）会诱发侧倾、弓背、向后运动和后肢外展——这些都是血清素（5-羟色胺，5-HT）综合征的组成部分。酮色林，一种5-HT-2受体拮抗剂，以及用5-HT神经毒素对氯苯丙氨酸（PCPA）进行预处理，可减轻这些行为异常的表现。这些结果表明，ABNMP可能会引起类似于对氯苯丙胺所引发的5-HT急性释放。