Van Voorhees A, Stenn K S
Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06510-8059.
Am J Dermatopathol. 1987 Dec;9(6):528-32. doi: 10.1097/00000372-198712000-00010.
A case is described of a patient with Bactrim-induced fixed drug eruption (FDE). Histological studies were performed at 1 day and 5 days after the drug exposure. While the 5-day-old lesion showed changes classically recognized as FDE, the 1-day-old lesion showed changes typical of a hypersensitivity response: diffuse spongiosis, dermal edema and hemorrhage, neutrophilic polymorphonuclear leukocyte abscess formations, and large numbers of eosinophils. This report underscores the dynamic cellular changes that occur in the evolving FDE lesion.
本文描述了一例因复方新诺明引起的固定性药疹（FDE）患者。在接触药物后的第1天和第5天进行了组织学研究。虽然5日龄的皮损显示出典型的FDE变化，但1日龄的皮损显示出超敏反应的典型变化：弥漫性海绵形成、真皮水肿和出血、嗜中性多形核白细胞脓肿形成以及大量嗜酸性粒细胞。本报告强调了在不断演变的FDE皮损中发生的动态细胞变化。
