Antonissen Gunther, Martel An
Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke 9820, Belgium; Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke 9820, Belgium.
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke 9820, Belgium.
Vet Clin North Am Exot Anim Pract. 2018 May;21(2):355-377. doi: 10.1016/j.cvex.2018.01.009.
The use of antifungals in birds is characterized by interspecies and interindividual variability in the pharmacokinetics, affecting drug safety and efficacy. Oral antifungal drug absorption is a complex process affected by drug formulation characteristics, gastrointestinal anatomy, and physiology. New antifungal drug delivery systems can enhance drug stability, reduce off-target side effects, prolong residence time in the blood, and improve efficacy. Topical administration of antifungals through nebulization shows promising results. However, therapeutic output is highly influenced by drug formulation and type of nebulizer, indicating these factors should be taken into account when selecting this medication route.
鸟类使用抗真菌药物的特点是药代动力学存在种间和个体间差异，这会影响药物的安全性和有效性。口服抗真菌药物的吸收是一个复杂的过程，受药物剂型特性、胃肠道解剖结构和生理功能的影响。新型抗真菌药物递送系统可以提高药物稳定性、减少脱靶副作用、延长血液中的停留时间并提高疗效。通过雾化进行抗真菌药物的局部给药显示出了有前景的结果。然而，治疗效果受药物剂型和雾化器类型的影响很大，这表明在选择这种给药途径时应考虑这些因素。
