Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USA.
Department of Biochemistry, Faculty of Medicine, Chiang-Mai University, Chiang-Mai, Thailand.
Clin Res Hepatol Gastroenterol. 2018 Oct;42(5):436-442. doi: 10.1016/j.clinre.2018.03.011. Epub 2018 Apr 11.
BACKGROUND/OBJECTIVES: Recent epidemiologic studies have suggested that appendectomy could be a risk factor for primary sclerosing cholangitis (PSC) although the results were inconsistent. This systematic review and meta-analysis was conducted to summarize all available evidence.
A comprehensive literature review was conducted using MEDLINE and EMBASE database through January 2018 to identify all studies that reported the risk of PSC among individuals who had appendectomy versus those with no history of appendectomy. Effect estimates from each study were extracted and combined together using the random-effect, generic inverse variance method of DerSimonian and Laird.
A total of 6 case-control studies with 2432 participants met the eligibility criteria and were included in the meta-analysis. The risk of PSC in individuals who had appendectomy was significantly higher than those with no history of appendectomy with the pooled odds ratio of 1.37 (95% CI: 1.15-1.63). The statistical heterogeneity was insignificant with an I2 of 0%.
A significantly increased risk of PSC among individuals who had a history of appendectomy was found in this study.
背景/目的：最近的流行病学研究表明，阑尾切除术可能是原发性硬化性胆管炎（PSC）的一个危险因素，尽管结果不一致。本系统评价和荟萃分析旨在总结所有现有证据。
通过 2018 年 1 月的 MEDLINE 和 EMBASE 数据库进行全面的文献检索，以确定所有报告阑尾切除术患者与无阑尾切除术史患者中 PSC 风险的研究。从每项研究中提取效应估计值，并使用 DerSimonian 和 Laird 的随机效应、通用逆方差方法合并在一起。
共有 6 项符合纳入标准的病例对照研究，共 2432 名参与者纳入荟萃分析。有阑尾切除术史的个体发生 PSC 的风险明显高于无阑尾切除术史的个体，合并优势比为 1.37（95%CI：1.15-1.63）。统计异质性不显著，I2 为 0%。
本研究发现，有阑尾切除术史的个体发生 PSC 的风险显著增加。
